Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | DDR1 | Q08345 | 6/20 | 0.57 |
| ▸ | DDR2 | Q16832 | 6/20 | 0.57 |
| ▸ | LCK | P06239 | 4/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.57 |
| ▸ | BRAF | P15056 | 4/20 | 0.57 |
| ▸ | SRC | P12931 | 3/20 | 0.57 |
| ▸ | EPHB2 | P29323 | 3/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | ESYT2 | A0FGR8 | 2/20 | 0.57 |
| ▸ | NBAS | A2RRP1 | 2/20 | 0.57 |
| ▸ | CNOT1 | A5YKK6 | 2/20 | 0.57 |
| ▸ | TBKBP1 | A7MCY6 | 2/20 | 0.57 |
| ▸ | AGPS | O00116 | 2/20 | 0.57 |
| ▸ | MYO1F | O00160 | 2/20 | 0.57 |
| ▸ | SNAP23 | O00161 | 2/20 | 0.57 |
| ▸ | AP3B1 | O00203 | 2/20 | 0.57 |
| ▸ | PSMD12 | O00232 | 2/20 | 0.57 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22024557 | 0.94 | PIKFYVE (0.61) | POLBKDM4EDDR1DDR2LCK | |
| SCHEMBL22024696 | 0.92 | ABL1 (0.67) | POLBKDM4EDDR1DDR2LCK | |
| SCHEMBL22024645 | 0.88 | BRAF (0.68) | POLBKDM4EDDR1DDR2LCK | |
| SCHEMBL21943451 | 0.87 | KDR (0.58) | POLBKDM4EDDR1DDR2LCK | |
| SCHEMBL22024869 | 0.86 | PIKFYVE (0.73) | DDR1DDR2LCKMAPK14BRAF | |
| SCHEMBL22024705 | 0.84 | PIKFYVE (0.75) | POLBKDM4EDDR1DDR2LCK | |
| SCHEMBL24532071 | 0.83 | POLB (0.68) | POLBKDM4EDDR1DDR2LCK | |
| SCHEMBL22025503 | 0.83 | POLB (0.63) | POLBKDM4EDDR1DDR2LCK | |
| SCHEMBL21943519 | 0.82 | CSF1R (0.54) | POLBKDM4EDDR1LCKMAPK14 | |
| SCHEMBL21943069 | 0.82 | KDR (0.51) | POLBKDM4EBRAFKDRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663293-A1 | SUBSTITUTED PENTA- AND HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | Xiamen University (CN) | 2020-06-10 | — | — | EP | disclosed |