Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.68 |
| ▸ | APEX1 | P27695 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | CSF1R | P07333 | 2/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.61 |
| ▸ | LCK | P06239 | 5/20 | 0.61 |
| ▸ | BRAF | P15056 | 4/20 | 0.61 |
| ▸ | KDR | P35968 | 4/20 | 0.61 |
| ▸ | TEK | Q02763 | 1/20 | 0.61 |
| ▸ | SRC | P12931 | 4/20 | 0.60 |
| ▸ | KIT | P10721 | 3/20 | 0.60 |
| ▸ | DDR1 | Q08345 | 5/20 | 0.60 |
| ▸ | DDR2 | Q16832 | 5/20 | 0.60 |
| ▸ | EPHB2 | P29323 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | ESYT2 | A0FGR8 | 2/20 | 0.56 |
| ▸ | NBAS | A2RRP1 | 2/20 | 0.56 |
| ▸ | CNOT1 | A5YKK6 | 2/20 | 0.56 |
| ▸ | TBKBP1 | A7MCY6 | 2/20 | 0.56 |
| ▸ | AGPS | O00116 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24532063 | 0.89 | POLB (0.67) | POLBAPEX1MAPTCSF1RMAPK14 | |
| SCHEMBL5023651 | 0.86 | POLB (0.68) | POLBAPEX1MAPTCSF1RMAPK14 | |
| SCHEMBL22024705 | 0.85 | PIKFYVE (0.75) | POLBAPEX1MAPTCSF1RMAPK14 | |
| SCHEMBL22025503 | 0.84 | POLB (0.63) | POLBAPEX1MAPTCSF1RMAPK14 | |
| SCHEMBL22065428 | 0.83 | POLB (0.58) | POLBAPEX1MAPTCSF1RMAPK14 | |
| SCHEMBL22025300 | 0.82 | BRAF (0.61) | POLBAPEX1MAPTCSF1RMAPK14 | |
| SCHEMBL22066392 | 0.82 | POLB (0.56) | POLBAPEX1MAPTCSF1RMAPK14 | |
| SCHEMBL22025315 | 0.81 | POLB (0.62) | POLBAPEX1MAPTCSF1RMAPK14 | |
| SCHEMBL22025324 | 0.81 | PIKFYVE (0.58) | POLBAPEX1MAPTCSF1RMAPK14 | |
| SCHEMBL22024645 | 0.81 | BRAF (0.68) | POLBAPEX1MAPTCSF1RMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220194943-A1 | RECEPTOR TYROSINE KINASE INHIBITORS FOR TREATMENT OF PROTEIN KINASE MODULATION-RESPONSIVE DISEASE OR DISORDER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (US) | 2022-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220194943-A1 | RECEPTOR TYROSINE KINASE INHIBITORS FOR TREATMENT OF PROTEIN KINASE MODULATION-RESPONSIVE DISEASE OR DISORDER | EPHA1, EPHB2, EPHB1 | POLB 4564/4885APEX1 3129/4885MAPT 1468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.