Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.40 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22066435 | 0.81 | POLB (0.49) | MAPTKDM4EMAPK1POLBAURKA | |
| SCHEMBL22025088 | 0.80 | MAPT (0.56) | MAPTKDM4ENPSR1MAPK1MPO | |
| SCHEMBL22024791 | 0.79 | MEN1 (0.57) | MAPTKDM4ENPSR1MAPK1MEN1 | |
| SCHEMBL22024619 | 0.77 | MAPT (0.56) | MAPTKDM4ENPSR1MAPK1POLB | |
| SCHEMBL22024786 | 0.75 | PIKFYVE (0.58) | MAPTKDM4ENPSR1MAPK1MEN1 | |
| SCHEMBL22025512 | 0.75 | BRAF (0.58) | MAPTKDM4ENPSR1MAPK1MPO | |
| SCHEMBL22025503 | 0.70 | POLB (0.63) | MAPTKDM4EMAPK1POLBAURKA | |
| SCHEMBL22024781 | 0.69 | PIKFYVE (0.65) | MAPTMAPK1POLBAURKABRAF | |
| SCHEMBL22024821 | 0.69 | PIKFYVE (0.62) | MAPTKDM4ENPSR1POLBBRAF | |
| SCHEMBL4286068 | 0.65 | MAPT (0.94) | MAPTPOLBMEN1KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663293-A1 | SUBSTITUTED PENTA- AND HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | Xiamen University (CN) | 2020-06-10 | — | — | EP | disclosed |