Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.47 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 3/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 5/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.43 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.43 |
| ▸ | ESYT2 | A0FGR8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22025503 | 0.82 | POLB (0.63) | POLBMAPTAPEX1DDR1DDR2 | |
| SCHEMBL22066247 | 0.81 | MAPT (0.44) | POLBMAPTBRAFKDM4EAURKA | |
| SCHEMBL22024781 | 0.81 | PIKFYVE (0.65) | POLBMAPTAPEX1DDR1DDR2 | |
| SCHEMBL22024821 | 0.76 | PIKFYVE (0.62) | POLBMAPTKITCSF1RBRAF | |
| SCHEMBL22024822 | 0.75 | PIKFYVE (0.74) | APEX1DDR1DDR2EPHB2LCK | |
| SCHEMBL22025088 | 0.71 | MAPT (0.56) | POLBMAPTBRAFKDM4EAURKA | |
| SCHEMBL22024791 | 0.70 | MEN1 (0.57) | MAPTAPEX1DDR1DDR2EPHB2 | |
| SCHEMBL22024619 | 0.70 | MAPT (0.56) | POLBMAPTBRAFKDM4EPIKFYVE | |
| SCHEMBL5023651 | 0.68 | POLB (0.68) | POLBMAPTAPEX1DDR1DDR2 | |
| SCHEMBL17131157 | 0.68 | MAPK14 (0.72) | POLBMAPTAPEX1DDR1DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663293-A1 | SUBSTITUTED PENTA- AND HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | Xiamen University (CN) | 2020-06-10 | — | — | EP | disclosed |