Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 7/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 5/20 | 0.42 |
| ▸ | BCR | P11274 | 4/20 | 0.42 |
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | BRAF | P15056 | 3/20 | 0.42 |
| ▸ | ESYT2 | A0FGR8 | 2/20 | 0.42 |
| ▸ | NBAS | A2RRP1 | 2/20 | 0.42 |
| ▸ | CNOT1 | A5YKK6 | 2/20 | 0.42 |
| ▸ | TBKBP1 | A7MCY6 | 2/20 | 0.42 |
| ▸ | AGPS | O00116 | 2/20 | 0.42 |
| ▸ | MYO1F | O00160 | 2/20 | 0.42 |
| ▸ | SNAP23 | O00161 | 2/20 | 0.42 |
| ▸ | AP3B1 | O00203 | 2/20 | 0.42 |
| ▸ | PSMD12 | O00232 | 2/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.42 |
| ▸ | PGRMC1 | O00264 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22024781 | 0.85 | PIKFYVE (0.65) | PIKFYVEKITABL1BCRPIM1 | |
| SCHEMBL22024822 | 0.85 | PIKFYVE (0.74) | PIKFYVEKITABL1BCRPIM1 | |
| SCHEMBL22024791 | 0.76 | MEN1 (0.57) | PIKFYVEKITMEN1KMT2AABL1 | |
| SCHEMBL22024786 | 0.76 | PIKFYVE (0.58) | PIKFYVEMEN1KMT2AABL1BCR | |
| SCHEMBL22024821 | 0.76 | PIKFYVE (0.62) | PIKFYVEKITBRAFPDGFRBRAF1 | |
| SCHEMBL22025503 | 0.76 | POLB (0.63) | PIKFYVEKITABL1BCRPIM1 | |
| SCHEMBL22066248 | 0.71 | MEN1 (0.43) | MEN1KMT2AABL1BCREGFR | |
| SCHEMBL22065281 | 0.71 | MEN1 (0.42) | MEN1KMT2AABL1BCRPRKD3 | |
| SCHEMBL22025017 | 0.70 | PIKFYVE (0.82) | PIKFYVEMEN1KMT2AABL1BCR | |
| SCHEMBL30675086 | 0.69 | PIKFYVE (1.00) | PIKFYVEKITABL1BCRPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663293-A1 | SUBSTITUTED PENTA- AND HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF | Xiamen University (CN) | 2020-06-10 | — | — | EP | disclosed |