Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.66 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.66 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.66 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.66 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.66 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.66 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.66 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.66 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.66 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | INPP5D | Q92835 | 1/20 | 0.57 |
| ▸ | OSBP | P22059 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29100493 | 1.00 | GPBAR1 (0.66) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL8332285 | 1.00 | GPBAR1 (0.66) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL31747501 | 0.92 | GPBAR1 (0.65) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL28181280 | 0.92 | GPBAR1 (0.65) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL28181279 | 0.92 | GPBAR1 (0.65) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL30575186 | 0.90 | EPHA2 (0.68) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL17912309 | 0.90 | EPHA2 (0.68) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL133953 | 0.90 | EPHA2 (0.68) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL1163247 | 0.90 | EPHA2 (0.65) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 | |
| SCHEMBL3447578 | 0.90 | EPHA2 (0.68) | GPBAR1EPHA2HSD17B10TDP1AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016660-B1 | SHIP INHIBITION TO COMBAT OBESITY | UNIV NEW YORK STATE RES FOUND (US) | 2020-06-10 | — | — | EP | disclosed |