Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | POLR1A | O95602 | 2/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22072095 | 0.88 | POLB (0.40) | POLBMAPTHTTSMN1; SMN2POLR1A | |
| SCHEMBL22072087 | 0.82 | POLB (0.43) | POLBMAPTHTTSMN1; SMN2POLR1A | |
| SCHEMBL22071741 | 0.82 | POLB (0.54) | POLBMAPTHTTSMN1; SMN2POLR1A | |
| SCHEMBL22072305 | 0.75 | BRD4 (0.36) | POLBMAPTHTTKDM4E | |
| SCHEMBL22071697 | 0.73 | MEN1 (0.42) | POLBMAPTHTTSMN1; SMN2CYP2D6 | |
| SCHEMBL22071696 | 0.73 | KDM4E (0.40) | POLBMAPTHTTSMN1; SMN2CYP2D6 | |
| SCHEMBL22071728 | 0.73 | MEN1 (0.50) | POLBMAPTHTTSMN1; SMN2CYP2D6 | |
| SCHEMBL22072088 | 0.72 | POLB (0.38) | POLBMAPTHTTSMN1; SMN2POLR1A | |
| SCHEMBL22071727 | 0.72 | MEN1 (0.41) | POLBMAPTHTTSMN1; SMN2CYP2D6 | |
| SCHEMBL22071736 | 0.72 | KMT2A (0.41) | MAPTSMN1; SMN2ATMALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020117974-A1 | COMPOUNDS AND COMPOSITIONS FOR EYE TREATMENTS | AVEDRO, INC. (US) | 2020-06-11 | — | — | WO | disclosed |