Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLR1A | O95602 | 2/20 | 0.37 |
| ▸ | ECE1 | P42892 | 1/20 | 0.37 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22071735 | 0.88 | POLB (0.39) | POLBMAPTHTTSMN1; SMN2POLR1A | |
| SCHEMBL22072305 | 0.86 | BRD4 (0.36) | POLBMAPTHTTKDM4E | |
| SCHEMBL22071741 | 0.83 | POLB (0.54) | POLBMAPTHTTSMN1; SMN2POLR1A | |
| SCHEMBL22072087 | 0.83 | POLB (0.43) | POLBMAPTHTTSMN1; SMN2POLR1A | |
| SCHEMBL22072149 | 0.78 | HPGD (0.41) | POLBMAPTHTTSMN1; SMN2KDM4E | |
| SCHEMBL22072182 | 0.77 | SMN1; SMN2 (0.39) | POLBMAPTHTTSMN1; SMN2KDM4E | |
| SCHEMBL22071696 | 0.75 | KDM4E (0.40) | POLBMAPTHTTSMN1; SMN2POLR1A | |
| SCHEMBL22071697 | 0.75 | MEN1 (0.42) | POLBMAPTHTTSMN1; SMN2POLR1A | |
| SCHEMBL22071728 | 0.74 | MEN1 (0.50) | POLBMAPTHTTSMN1; SMN2POLR1A | |
| SCHEMBL22071695 | 0.73 | KDM4E (0.39) | POLBMAPTHTTSMN1; SMN2POLR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020117974-A1 | COMPOUNDS AND COMPOSITIONS FOR EYE TREATMENTS | AVEDRO, INC. (US) | 2020-06-11 | — | — | WO | disclosed |