Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 4/20 | 0.72 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.63 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.63 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.62 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.58 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 4/20 | 0.56 |
| ▸ | GSK3B | P49841 | 4/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 2/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12430667 | 0.91 | ULK1 (0.86) | ULK1PDK1ULK2NTRK1NTRK3 | |
| SCHEMBL31471779 | 0.91 | ULK1 (0.86) | ULK1PDK1ULK2NTRK1NTRK3 | |
| SCHEMBL12430703 | 0.89 | ULK1 (0.73) | ULK1PDK1ULK2NTRK1NTRK3 | |
| SCHEMBL12430668 | 0.88 | ULK1 (0.72) | ULK1PDK1ULK2NTRK1NTRK3 | |
| SCHEMBL12430693 | 0.87 | ULK1 (0.68) | ULK1PDK1ULK2NTRK1NTRK3 | |
| SCHEMBL7108312 | 0.85 | ULK1 (0.68) | ULK1PDK1ULK2NTRK1NTRK3 | |
| SCHEMBL12430694 | 0.85 | ULK1 (0.68) | ULK1PDK1ULK2NTRK1NTRK3 | |
| SCHEMBL12430692 | 0.84 | ULK1 (0.64) | ULK1PDK1ULK2NTRK1NTRK3 | |
| SCHEMBL12430682 | 0.84 | ULK1 (0.75) | ULK1PDK1ULK2NTRK1NTRK3 | |
| SCHEMBL31471772 | 0.84 | ULK1 (0.81) | ULK1PDK1ULK2NTRK1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020118183-A1 | 2,4-DIAMINOPYRIMIDINE BICYCLES FOR TREATING CANCER | KAPOOR TARUN M (US) | 2020-06-11 | — | — | WO | disclosed |