Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPAST | Q9UBP0 | 2/20 | 0.61 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 6/20 | 0.42 |
| ▸ | SRC | P12931 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 4/20 | 0.42 |
| ▸ | IGF1R | P08069 | 4/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.41 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | ULK1 | O75385 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22035049 | 0.76 | SPAST (1.00) | SPASTPAK4PAK1IGF1R | |
| SCHEMBL22035048 | 0.76 | SPAST (1.00) | SPASTPAK4PAK1IGF1R | |
| SCHEMBL4073913 | 0.74 | SPAST (0.58) | SPASTAURKASRCGSK3BIGF1R | |
| SCHEMBL7028703 | 0.74 | AURKA (0.72) | SPASTAURKASRCGSK3BAURKB | |
| SCHEMBL22072048 | 0.73 | SPAST (0.77) | SPASTPAK4PAK1AURKAIGF1R | |
| SCHEMBL5255520 | 0.68 | HRH4 (0.65) | PAK4PAK1AURKASRCGSK3B | |
| SCHEMBL801474 | 0.68 | CYP1A2 (0.63) | SPASTAURKASRCGSK3BAURKB | |
| SCHEMBL31471834 | 0.68 | PAK4 (0.56) | PAK4PAK1SRCGSK3BIGF1R | |
| SCHEMBL22072524 | 0.67 | PAK4 (0.83) | PAK4PAK1IGF1RHRH4 | |
| SCHEMBL31471972 | 0.67 | PAK4 (0.83) | PAK4PAK1IGF1RHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020118183-A1 | 2,4-DIAMINOPYRIMIDINE BICYCLES FOR TREATING CANCER | KAPOOR TARUN M (US) | 2020-06-11 | — | — | WO | disclosed |