SPAST — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL22035048	1.00	2/20
SCHEMBL22035049	1.00	2/20
SCHEMBL22035095	1.00	2/20
SCHEMBL22035098	1.00	2/20
SCHEMBL30129663	1.00	2/20
SCHEMBL22072048	0.77	2/20
SCHEMBL22072740	0.76	2/20
SCHEMBL22072741	0.76	2/20
SCHEMBL22072528	0.75	2/20
SCHEMBL22072737	0.75	2/20
SCHEMBL22034758	0.74	2/20
SCHEMBL22034761	0.74	2/20
SCHEMBL22072742	0.72	2/20
SCHEMBL22072083	0.61	2/20
SCHEMBL22072084	0.56	2/20
SCHEMBL22034762	0.54	2/20
SCHEMBL22072081	0.72	1/20
SCHEMBL22072526	0.67	1/20
SCHEMBL22072735	0.67	1/20
SCHEMBL22072736	0.66	1/20

Clinical trials — most relevant to SPAST by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
D-Cycloserine for Serine Palmitoyltransferase Inhibition	PHASE4	COMPLETED
Spondyloarthritis: Inducing Drug-free Remission by Early TNF-alpha Blockade	PHASE3	ACTIVE_NOT_RECRUITING
Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia	PHASE2/PHASE3	COMPLETED
Cognitive Disorders in Hereditary Spastic Paraplegia Type 4	nan	UNKNOWN
Evaluation of an Intensive Training Program for Patients with Hereditary Spastic Paraparesis SPG4/Spast	nan	RECRUITING
Prevelance of Axial Spondylosis Arthritis in Inflammatory Bowel Disease and Its RESPONSE to Tumour Necrosis Factor (TNF) Inhibitors Treatment in Assiut University Hospital	nan	NOT_YET_RECRUITING
Efficacy of Pain Neuroscience Education and Physiotherapy in Patients Diagnosed with Spondyloarthritis	nan	COMPLETED
Phenotypes, Biomarkers and Pathophysiology in Spastic Ataxias	nan	UNKNOWN
Consequences of Mutations in the SPG7 Gene at the Heterozygous State	nan	COMPLETED
Spastic Paraplegia - Centers of Excellence Research Network	nan	RECRUITING
Studying Cognition in SPG4	nan	COMPLETED
The Role of IL-23 in Chronic Inflammatory Disease: Exploring the Cellular and Molecular Targets of IL-23 Signaling in Peripheral and Axial Spondyloarthritis	nan	RECRUITING
Spondyloarthritis Inception Cohort of Southern Denmark	nan	ENROLLING_BY_INVITATION
Benefits of Spa Therapy in Saint-Lary Soulan for Knee Osteoarthritis	nan	COMPLETED
Retrospective Case-Control Study for Developing an Artificial Intelligence (AI) Tool for Lesion Detection Using Magnetic Resonance Imaging (MRI) and Clinical Variables for Early Diagnosis of Axial Spondyloarthritis (axSpA)	nan	COMPLETED
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)	nan	RECRUITING
Online Regional Anesthesia Resources - Are They Effective?	nan	COMPLETED
Imaging Biomarkers in Crohn's Associated Spondyloarthritis	nan	COMPLETED
National Psoriasis Foundation - Dendritic Cell-Specific Transmembrane Protein (DC-Stamp) Biomarker Study	nan	COMPLETED
Effect of Aerobic Exercises on Axial Spondyloarthropathy	nan	COMPLETED
Role of LILRA3 in Ankylosing Spondylitis and Axial Psoriatic Patients	nan	UNKNOWN
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia	nan	RECRUITING
Impact of Environmental Factors on Disease Activity in Spondyloarthritis (SPA): Results of the Prospective Co-Env Cohort	nan	COMPLETED
WEB-Based Physiotherapy for People With Axial Spondyloarthritis	nan	UNKNOWN
Referral Recommendations for Axial Spondyloarthritis	nan	COMPLETED
Socio-economic Determinants for Acceptance and Choice of Biological Treatment	nan	COMPLETED
A Study of Novel Immune Modulating Biomarkers in Patients With Spondyloarthritis With Axial Involvement	nan	COMPLETED
Natural History and Development of Spondyloarthritis	nan	RECRUITING
Serum Prostatic Specific Antigen Changes After Bipolar and Monopolar TURP	nan	UNKNOWN
Bidirectional Cohort Study of Nanfang Spondyloarthritis	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a SPAST binder may also engage these)

Protein	Name	Similarity
Q5ZK92	—	1.000	Q5ZK92 →
Q05AS3	—	1.000	Q05AS3 →
B2RYN7	—	1.000	B2RYN7 →
A2VDN5	—	0.999	A2VDN5 →
Q6AZT2	—	0.999	Q6AZT2 →
B4NBP4	—	0.997	B4NBP4 →
Q719N1	—	0.997	Q719N1 →
Q6NW58	—	0.996	Q6NW58 →
B3M301	—	0.996	B3M301 →
B7PXE3	—	0.996	B7PXE3 →
Q9QYY8	—	0.995	Q9QYY8 →
Q298L4	—	0.994	Q298L4 →
O43078	—	0.994	O43078 →
KATNA1	Katanin p60 ATPase-containing subunit A1	0.992	landscape →
Q6E0V2	—	0.992	Q6E0V2 →
Q4R407	—	0.992	Q4R407 →
Q9WV86	—	0.992	Q9WV86 →
B3P8A3	—	0.992	B3P8A3 →
B4JII0	—	0.991	B4JII0 →
B4K799	—	0.991	B4K799 →
B4G437	—	0.991	B4G437 →
Q9D3R6	—	0.991	Q9D3R6 →
Q3B8D5	—	0.990	Q3B8D5 →
Q6PGC1	—	0.990	Q6PGC1 →
B4PL32	—	0.990	B4PL32 →
Q1HGK7	—	0.990	Q1HGK7 →
Q0IIR9	—	0.990	Q0IIR9 →
Q8I0P1	—	0.989	Q8I0P1 →
A3KMI0	—	0.989	A3KMI0 →
Q8CDM1	—	0.989	Q8CDM1 →