Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.39 |
| ▸ | ITGAV | P06756 | 2/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2210571 | 1.00 | ALDH1A1 (0.42) | ALDH1A1HSD17B10CYP19A1EPHX1MAPT | |
| SCHEMBL2205850 | 0.88 | EPHX2 (0.44) | EPHX1LMNAMAPK1ITGB3ITGB1 | |
| SCHEMBL2207565 | 0.85 | MEN1 (0.38) | LMNAMAPK1ITGB3ITGB1ITGAV | |
| SCHEMBL2205140 | 0.84 | EPHX2 (0.48) | ALDH1A1 | |
| SCHEMBL2204827 | 0.84 | EPHX2 (0.48) | ALDH1A1 | |
| SCHEMBL2208558 | 0.84 | EPHX2 (0.48) | ALDH1A1 | |
| SCHEMBL4620794 | 0.82 | CYP19A1 (0.42) | ALDH1A1HSD17B10CYP19A1EPHX1MAPT | |
| SCHEMBL2207440 | 0.80 | TRPV1 (0.46) | ALDH1A1CYP2C19 | |
| SCHEMBL2207438 | 0.80 | TRPV1 (0.46) | ALDH1A1CYP2C19 | |
| SCHEMBL2209768 | 0.80 | TRPV1 (0.46) | ALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981883-B2 | Substituted spiro-compounds and the use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-07-19 | — | — | US | disclosed |