Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22075934 | 0.92 | PARP1 (0.47) | POLBALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL22075954 | 0.92 | PARP1 (0.47) | POLBALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL22075945 | 0.89 | POLB (0.40) | POLBALDH1A1MAPK1TSHRNPSR1 | |
| SCHEMBL22075920 | 0.84 | PARP1 (0.45) | POLBALDH1A1MAPK1TSHRLMNA | |
| SCHEMBL29040445 | 0.84 | HPGD (0.46) | POLBALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL30457557 | 0.84 | HPGD (0.46) | POLBALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL22075928 | 0.82 | PARP1 (0.43) | ALDH1A1MAPK1TSHRNPSR1LMNA | |
| SCHEMBL22075936 | 0.82 | PARP1 (0.43) | ALDH1A1MAPK1TSHRNPSR1LMNA | |
| SCHEMBL22075950 | 0.82 | PARP1 (0.46) | ALDH1A1TSHRLMNASMN1; SMN2TP53 | |
| SCHEMBL22075949 | 0.81 | TSHR (0.56) | POLBALDH1A1MAPK1TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691984-B2 | Compounds and methods for DCAF-mediated protein degradation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-07-04 | — | — | US | disclosed |
| US-11691984-B2 | Compounds and methods for DCAF-mediated protein degradation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-07-04 | — | — | US | disclosed |
| US-11691984-B2 | Compounds and methods for DCAF-mediated protein degradation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-07-04 | — | — | US | disclosed |
| EP-3864030-A1 | COMPOUNDS AND METHODS FOR DCAF-MEDIATED PROTEIN DEGRADATION | The Scripps Research Institute (US) | 2021-08-18 | — | — | EP | disclosed |
| US-20200190105-A1 | COMPOUNDS AND METHODS FOR DCAF-MEDIATED PROTEIN DEGRADATION | THE SCRIPPS RESEARCH INSTITUTE | 2020-06-18 | — | — | US | disclosed |
| US-20200190105-A1 | COMPOUNDS AND METHODS FOR DCAF-MEDIATED PROTEIN DEGRADATION | THE SCRIPPS RESEARCH INSTITUTE | 2020-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200190105-A1 | COMPOUNDS AND METHODS FOR DCAF-MEDIATED PROTEIN DEGRADATION | DCAF1, CUL4A, DCAF15 | POLB 2891/4885ALDH1A1 2600/4885MAPK1 3651/4885 |
| US-11691984-B2 | Compounds and methods for DCAF-mediated protein degradation | DCAF1, CUL4A, DCAF15 | POLB 2891/4885ALDH1A1 2600/4885MAPK1 3651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.