Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2207882 | 1.00 | S1PR1 (0.42) | S1PR1S1PR3 | |
| SCHEMBL1860375 | 0.92 | S1PR1 (0.45) | S1PR1S1PR3 | |
| SCHEMBL1860374 | 0.92 | S1PR1 (0.45) | S1PR1S1PR3 | |
| SCHEMBL1862015 | 0.86 | S1PR1 (0.49) | S1PR1S1PR3 | |
| SCHEMBL12214294 | 0.86 | S1PR1 (0.49) | S1PR1S1PR3 | |
| SCHEMBL1853967 | 0.85 | S1PR1 (0.45) | S1PR1S1PR3 | |
| SCHEMBL12214391 | 0.85 | S1PR1 (0.45) | S1PR1S1PR3 | |
| SCHEMBL2202454 | 0.84 | S1PR1 (0.47) | S1PR1S1PR3 | |
| SCHEMBL2202452 | 0.84 | S1PR1 (0.47) | S1PR1S1PR3 | |
| SCHEMBL12214389 | 0.83 | S1PR1 (0.45) | S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981924-B2 | Thiophene derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-07-19 | — | — | US | disclosed |
| US-20080300294-A1 | Novel Thiophene Derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2008-12-04 | — | — | US | disclosed |
| EP-1954688-A1 | NOVEL THIOPHENE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007060626-A1 | NOVEL THIOPHENE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300294-A1 | Novel Thiophene Derivatives | TPMT, TSLP, NFATC1 | S1PR1 1258/4885S1PR3 1088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.