Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 3/20 | 0.49 |
| ▸ | PLK4 | O00444 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 6/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | IGF1R | P08069 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 7/20 | 0.41 |
| ▸ | JAK3 | P52333 | 6/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL220647 | 0.81 | PAK4 (0.57) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL343410 | 0.81 | PAK4 (0.54) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL3993234 | 0.77 | PAK4 (0.49) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL4788903 | 0.77 | PAK4 (0.49) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL3852266 | 0.76 | DAO (0.47) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL15830141 | 0.76 | JAK2 (0.43) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL24350501 | 0.75 | PIK3C3 (0.54) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL4116079 | 0.75 | PAK4 (0.48) | PAK4PLK4MEN1HTTKMT2A | |
| SCHEMBL2321825 | 0.75 | IGF1R (0.56) | PAK4PLK4IGF1RFGFR1KDR | |
| SCHEMBL3939475 | 0.74 | PAK4 (0.56) | PAK4PLK4MEN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020114474-A1 | HETEROCYCLIC COMPOUND, APPLICATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | 苏州信诺维医药科技有限公司 | 2020-06-11 | — | — | WO | disclosed |