Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 5/20 | 0.56 |
| ▸ | PLK4 | O00444 | 4/20 | 0.56 |
| ▸ | AURKA | O14965 | 10/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | IGF1R | P08069 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | JAK3 | P52333 | 2/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.53 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10294569 | 0.86 | PAK4 (0.49) | PAK4PLK4AURKAAURKBFGFR1 | |
| SCHEMBL10294568 | 0.80 | AURKA (0.56) | AURKAAURKB | |
| SCHEMBL343410 | 0.79 | PAK4 (0.54) | PAK4PLK4AURKAAURKBFGFR1 | |
| SCHEMBL220647 | 0.79 | PAK4 (0.57) | PAK4PLK4AURKAAURKBFGFR1 | |
| SCHEMBL10312057 | 0.79 | AURKA (0.51) | PAK4PLK4AURKAAURKBFGFR1 | |
| SCHEMBL3936147 | 0.79 | NTRK1 (0.60) | AURKAAURKBJAK2IGF1RJAK3 | |
| SCHEMBL21925754 | 0.79 | AURKA (0.47) | PAK4PLK4AURKAAURKBFGFR1 | |
| SCHEMBL219046 | 0.78 | PAK4 (0.59) | PAK4PLK4AURKAAURKBFGFR1 | |
| SCHEMBL588674 | 0.77 | PAK4 (0.62) | PAK4PLK4AURKAAURKBFGFR1 | |
| SCHEMBL22600946 | 0.74 | PAK4 (0.59) | PAK4PLK4AURKAAURKBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016410-A2 | CHEMICAL COMPOUNDS 831 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |