Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.70 |
| ▸ | EP300 | Q09472 | 2/20 | 0.70 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.70 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.70 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.70 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 4/20 | 0.65 |
| ▸ | HPGD | P15428 | 4/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485855 | 0.97 | IDO1 (0.73) | IDO1EP300KAT2BKAT8HDAC3 | |
| SCHEMBL8371459 | 0.97 | IDO1 (0.73) | IDO1EP300KAT2BKAT8HDAC3 | |
| SCHEMBL29393764 | 0.97 | IDO1 (0.73) | IDO1EP300KAT2BKAT8HDAC3 | |
| SCHEMBL8006509 | 0.97 | IDO1 (0.73) | IDO1EP300KAT2BKAT8HDAC3 | |
| SCHEMBL29702452 | 0.97 | IDO1 (0.73) | IDO1EP300KAT2BKAT8HDAC3 | |
| SCHEMBL29706585 | 0.95 | IDO1 (0.70) | IDO1EP300KAT2BKAT8HDAC3 | |
| Hydrochloric Acid SCHEMBL28651123 | 0.95 | IDO1 (0.70) | IDO1EP300KAT2BKAT8HDAC3 | |
| SCHEMBL7991048 | 0.88 | IDO1 (0.55) | IDO1EP300KAT2BKAT8HDAC3 | |
| Putrescine SCHEMBL7991111 | 0.85 | IDO1 (0.57) | IDO1EP300KAT2BKAT8HDAC3 | |
| 4-Aminophenol SCHEMBL9806770 | 0.85 | IDO1 (0.57) | IDO1EP300KAT2BKAT8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981883-B2 | Substituted spiro-compounds and the use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-07-19 | — | — | US | disclosed |
| US-20090275628-A1 | Substituted Spiro-Compounds And The Use Thereof For Producing Medicaments | GRUENENTHAL GMBH (DE) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275628-A1 | Substituted Spiro-Compounds And The Use Thereof For Producing Medicaments | REN, PKD1, PKD2 | IDO1 4585/4885EP300 421/4885KAT2B 3319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.