Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Naphthoquinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.52 |
| ▸ | CDC25B | P30305 | 6/20 | 0.93 |
| ▸ | IDO1 | P14902 | 6/20 | 0.93 |
| ▸ | MAOA | P21397 | 3/20 | 0.93 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.93 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.93 |
| ▸ | MAOB | P27338 | 2/20 | 0.93 |
| ▸ | SNCA | P37840 | 2/20 | 0.93 |
| ▸ | AKT1 | P31749 | 1/20 | 0.93 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.93 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.93 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.93 |
| ▸ | MEN1 | O00255 | 7/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | RECQL | P46063 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthoquinone SCHEMBL14764194 | 0.97 | CDC25B (0.88) | CDC25BIDO1MAOAPIN1EHMT2 | |
| Naphthoquinone SCHEMBL11359780 | 0.97 | IDO1 (1.00) | CDC25BIDO1MAOAPIN1EHMT2 | |
| Naphthoquinone SCHEMBL8861335 | 0.97 | IDO1 (1.00) | CDC25BIDO1MAOAPIN1EHMT2 | |
| Naphthoquinone SCHEMBL29354680 | 0.97 | IDO1 (1.00) | CDC25BIDO1MAOAPIN1EHMT2 | |
| Naphthoquinone SCHEMBL42139 | 0.97 | IDO1 (1.00) | CDC25BIDO1MAOAPIN1EHMT2 | |
| Naphthoquinone SCHEMBL11229112 | 0.93 | IDO1 (0.93) | CDC25BIDO1MAOAPIN1EHMT2 | |
| Naphthoquinone SCHEMBL2722901 | 0.93 | IDO1 (0.93) | CDC25BIDO1MAOAPIN1EHMT2 | |
| Naphthoquinone SCHEMBL11341909 | 0.93 | IDO1 (0.93) | CDC25BIDO1MAOAPIN1EHMT2 | |
| Naphthoquinone SCHEMBL9262622 | 0.93 | IDO1 (0.93) | CDC25BIDO1MAOAPIN1EHMT2 | |
| Naphthoquinone SCHEMBL14763779 | 0.93 | IDO1 (0.93) | CDC25BIDO1MAOAPIN1EHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3018116-B1 | VITAMIN K2 INTERMEDIATES | KAPPA BIOSCIENCE AS (NO) | 2020-10-28 | — | — | EP | disclosed |
| US-10472314-B2 | Process for the preparation of vitamin K2 | KAPPA BIOSCIENCE AS (NO) | 2019-11-12 | — | — | US | disclosed |
| US-20170283354-A1 | PROCESS FOR THE PREPARATION OF VITAMIN K2 | KAPPA BIOSCIENCE AS (NO) | 2017-10-05 | — | — | US | disclosed |
| EP-3018116-A1 | VITAMIN K2 INTERMEDIATES | Kappa Bioscience As (NO) | 2016-05-11 | — | — | EP | disclosed |
| EP-2346806-B1 | PROCESS FOR THE PREPARATION OF VITAMIN K2 | KAPPA BIOSCIENCE AS (NO) | 2016-01-06 | — | — | EP | disclosed |
| US-20150210620-A1 | PROCESS FOR THE PREPARATION OF VITAMIN K2 | KAPPA BIOSCIENCE AS (NO) | 2015-07-30 | — | — | US | disclosed |
| US-9012693-B2 | Process for the preparation of vitamin K2 | KAPPA BIOSCIENCE AS (NO) | 2015-04-21 | — | — | US | disclosed |
| WO-2011117324-A2 | PROCESS FOR THE PREPARATION OF VITAMIN K2 | KAPPA BIOSCIENCE AS (NO) | 2011-09-29 | — | — | WO | disclosed |
| US-20110207967-A1 | PROCESS FOR THE PREPARATION OF VITAMIN K2 | KAPPA BIOSCIENCE AS (NO) | 2011-08-25 | — | — | US | disclosed |
| EP-2346806-A1 | PROCESS FOR THE PREPARATION OF VITAMIN K2 | Kappa Bioscience As (NO) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010035000-A1 | PROCESS FOR THE PREPARATION OF VITAMIN K2 | KAPPA BIOSCIENCE AS (NO) | 2010-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472314-B2 | Process for the preparation of vitamin K2 | PROC, VKORC1, VKORC1L1 | ACHE 2118/4885CDC25B 2162/4885IDO1 2104/4885 |
| US-20170283354-A1 | PROCESS FOR THE PREPARATION OF VITAMIN K2 | PROC, VKORC1, VKORC1L1 | ACHE 2316/4885CDC25B 2456/4885IDO1 2303/4885 |
| US-20110207967-A1 | PROCESS FOR THE PREPARATION OF VITAMIN K2 | PROC, VKORC1, VKORC1L1 | ACHE 2186/4885CDC25B 2346/4885IDO1 2327/4885 |
| US-20150210620-A1 | PROCESS FOR THE PREPARATION OF VITAMIN K2 | PROC, VKORC1, VKORC1L1 | ACHE 2316/4885CDC25B 2456/4885IDO1 2303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.