SCHEMBL22085136

SCHEMBL22085136

Nc1nc(C2=CC=CCC2)nc(-c2ccccc2)n1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 6/20 0.53
ADORA1 P30542 6/20 0.53
ADORA3 P0DMS8 3/20 0.53
ADORA2B P29275 2/20 0.53
POLB P06746 1/20 0.53
ALOX15 P16050 1/20 0.45
TSHR P16473 1/20 0.45
HRH4 Q9H3N8 1/20 0.44
HSP90AA1 P07900 1/20 0.43
HSP90AB1 P08238 1/20 0.43
NPSR1 Q6W5P4 1/20 0.40
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
ALDH1A1 P00352 2/20 0.39
MAPT P10636 2/20 0.39
HPGD P15428 2/20 0.39
HTT P42858 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.37
RAB9A P51151 2/20 0.35
NPC1 O15118 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18904706 0.92 L3MBTL1 (0.42) ADORA2AADORA1ADORA3ADORA2BPOLB
SCHEMBL27456903 0.89 L3MBTL1 (0.40) ADORA2AADORA1ADORA3ADORA2BPOLB
SCHEMBL19791233 0.85 L3MBTL1 (0.37) ADORA2AADORA1ADORA3ADORA2BPOLB
SCHEMBL22650686 0.85 MEN1 (0.38) ADORA2AADORA1ADORA3ADORA2BPOLB
SCHEMBL20662951 0.85 L3MBTL1 (0.37) ADORA2AADORA1ADORA3ADORA2BPOLB
SCHEMBL24727190 0.85 L3MBTL1 (0.58) ADORA2AADORA1ADORA3ADORA2BPOLB
SCHEMBL17528761 0.84 L3MBTL1 (0.43) ADORA2AADORA1ADORA3POLBHRH4
SCHEMBL21343654 0.84 NR1H4 (0.43) POLBHRH4NPSR1MEN1KMT2A
SCHEMBL27446980 0.82 MEN1 (0.36) ADORA2AADORA1ADORA3ADORA2BPOLB
SCHEMBL19072869 0.82 ACP1 (0.35) ADORA2AADORA1ADORA3ADORA2BPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3663283-A1 CONDENSED CYCLIC COMPOUND, COMPOSITION INCLUDING THE SAME, AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THIN FILM FORMED FROM THE COMPOSITION Samsung Display Co., Ltd. (KR) 2020-06-10 EP disclosed