Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15213138 | 1.00 | GPR84 (0.56) | GPR84SLC6A4NR4A2MTNR1AMTNR1B | |
| SCHEMBL10068459 | 0.82 | GPR84 (0.55) | GPR84SLC6A4NR4A2MTNR1AMTNR1B | |
| SCHEMBL16360806 | 0.81 | MEN1 (0.51) | GPR84SLC6A4NR3C1NR3C2PGR | |
| SCHEMBL3184502 | 0.79 | GPR84 (0.67) | GPR84SLC6A4NR4A2MTNR1AMTNR1B | |
| SCHEMBL14898398 | 0.79 | GPR84 (0.55) | GPR84SLC6A4NR4A2MTNR1AMTNR1B | |
| SCHEMBL19661499 | 0.79 | GPR84 (0.55) | GPR84SLC6A4NR4A2MTNR1AMTNR1B | |
| SCHEMBL4492495 | 0.77 | GPR84 (0.52) | GPR84SLC6A4NR4A2MTNR1AMTNR1B | |
| SCHEMBL4505527 | 0.76 | GPR84 (0.63) | GPR84SLC6A4NR4A2NR3C1NR3C2 | |
| SCHEMBL3195765 | 0.74 | GPR84 (0.73) | GPR84SLC6A4NR4A2MTNR1AMTNR1B | |
| SCHEMBL27929621 | 0.74 | GPR84 (1.00) | GPR84SLC6A4NR4A2ADRB3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3769776-A1 | PEPTIDOMIMETIC MACROCYCLES | Aileron Therapeutics, Inc. (US) | 2021-01-27 | — | — | EP | disclosed |
| EP-2822572-B1 | PEPTIDOMIMETIC MACROCYCLES | AILERON THERAPEUTICS INC (US) | 2020-06-10 | — | — | EP | disclosed |