Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.62 |
| ▸ | EGFR | P00533 | 9/20 | 0.62 |
| ▸ | ABL1 | P00519 | 7/20 | 0.62 |
| ▸ | ABL2 | P42684 | 7/20 | 0.62 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 3/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | TEK | Q02763 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LYN | P07948 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | RGS12 | O14924 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22086527 | 0.79 | ABL1 (0.39) | SRCEGFRABL1ABL2GAA | |
| SCHEMBL25065700 | 0.79 | ABL1 (0.39) | SRCEGFRABL1ABL2GAA | |
| SCHEMBL5936173 | 0.79 | SRC (0.97) | SRCEGFRABL1ABL2MAPT | |
| SCHEMBL25066212 | 0.79 | SRC (0.45) | SRCEGFRABL1ABL2MAPT | |
| SCHEMBL25066043 | 0.78 | CCNE1 (0.39) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL16610617 | 0.77 | SRC (0.46) | SRCEGFRABL1ABL2MAPT | |
| SCHEMBL22086528 | 0.75 | PDE9A (0.43) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL132510 | 0.74 | SRC (1.00) | SRCEGFRABL1ABL2MAPT | |
| SCHEMBL15265113 | 0.74 | SRC (0.68) | SRCMAPTLMNAGAAHTT | |
| SCHEMBL25066089 | 0.73 | SRC (1.00) | SRCEGFRABL1ABL2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020115481-A1 | MAP4K4 INHIBITORS | IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE (GB) | 2020-06-11 | — | — | WO | disclosed |