Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2205914 | 0.88 | HDAC1 (0.54) | HDAC1GPR119HDAC2HDAC3 | |
| SCHEMBL2207150 | 0.88 | HDAC1 (0.42) | HDAC1GPR119HDAC2 | |
| SCHEMBL2207954 | 0.84 | HDAC1 (0.46) | HDAC1GPR119DRD2DRD4HTR2A | |
| SCHEMBL2208702 | 0.80 | HDAC1 (0.56) | HDAC1HDAC2 | |
| SCHEMBL4580585 | 0.80 | FFAR1 (0.50) | HDAC1GPR119 | |
| SCHEMBL5767875 | 0.77 | GPR119 (0.42) | HDAC1GPR119HDAC2HDAC3 | |
| SCHEMBL4505385 | 0.76 | GPR119 (0.41) | HDAC1GPR119HDAC2HDAC3SLC6A4 | |
| SCHEMBL4578927 | 0.75 | TNFRSF1A (0.46) | HDAC1GPR119HDAC2HDAC3 | |
| SCHEMBL4518353 | 0.75 | GPR119 (0.40) | HDAC1GPR119HDAC2HDAC3 | |
| SCHEMBL2207945 | 0.74 | HDAC1 (0.76) | HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981874-B2 | Phosphorus derivatives as histone deacetylase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2011-07-19 | — | — | US | disclosed |
| US-20090270351-A1 | PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270351-A1 | PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | HDAC5, PPM1A, PTEN | HDAC1 4/4885GPR119 2507/4885DRD2 4699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.