Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nateglinide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | ATM | Q13315 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | PLG | P00747 | 1/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nateglinide SCHEMBL9232138 | 1.00 | LMNA (1.00) | LMNATDP1PSMB5ALDH1A1KMT2A | |
| (S)-Nateglinide SCHEMBL3182743 | 1.00 | LMNA (1.00) | LMNATDP1PSMB5ALDH1A1KMT2A | |
| Nateglinide SCHEMBL3182738 | 1.00 | LMNA (1.00) | LMNATDP1PSMB5ALDH1A1KMT2A | |
| Nateglinide SCHEMBL1692510 | 1.00 | LMNA (1.00) | LMNATDP1PSMB5ALDH1A1KMT2A | |
| Nateglinide SCHEMBL22571 | 1.00 | LMNA (1.00) | LMNATDP1PSMB5ALDH1A1KMT2A | |
| Nateglinide SCHEMBL1536880 | 1.00 | LMNA (1.00) | LMNATDP1PSMB5ALDH1A1KMT2A | |
| Nateglinide SCHEMBL303827 | 1.00 | LMNA (1.00) | LMNATDP1PSMB5ALDH1A1KMT2A | |
| Nateglinide SCHEMBL14199702 | 1.00 | LMNA (1.00) | LMNATDP1PSMB5ALDH1A1KMT2A | |
| Nateglinide SCHEMBL5692027 | 0.99 | LMNA (0.97) | LMNATDP1PSMB5ALDH1A1KMT2A | |
| Nateglinide SCHEMBL3911164 | 0.99 | LMNA (0.97) | LMNATDP1PSMB5ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 28782 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122059842-A | Synthesis method for improving purity of nateglinide | 天方药业有限公司 | 2026-05-19 | — | — | CN | claimed |
| US-20260124282-A1 | DECORIN FOR ITS USE IN THE TREATMENT OF DIABETES | CENTRE EUROPEEN D'ETUDE DU DIABETE (FR) | 2026-05-07 | — | — | US | claimed |
| US-20260115210-A1 | METHOD FOR TREATING SUBJECTS SUFFERING FROM CENTRAL NERVOUS SYSTEM CONTUSIONS | REMEDY PHARMACEUTICALS, INC. (US) | 2026-04-30 | — | — | US | claimed |
| US-12611416-B2 | Methods of treating ischemic stroke at risk for cerebral or cerebellar edema | REMEDY PHARMACEUTICALS, INC. (US) | 2026-04-28 | — | — | US | claimed |
| US-12599564-B2 | Antidiabetic pharmaceutical compositions | Elite Pharmaceutical Solution Inc. (US) | 2026-04-14 | — | — | US | claimed |
| US-20260085061-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | SITRYX THERAPEUTICS LIMITED (GB) | 2026-03-26 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20260069550-A1 | TRANSDERMAL DELIVERY OF ANTIDIABETIC AGENTS | RITTENHOUSE CHRISTINE (US) | 2026-03-12 | — | — | US | claimed |
| US-20260069593-A1 | METHODS FOR TREATING CANCER | AMGEN INC (US) | 2026-03-12 | — | — | US | claimed |
| EP-4684799-A2 | ANTIBODIES THAT DISRUPT THE INTERACTION OF GAL3 AND INSULIN RECEPTOR OR INTEGRINS AND METHODS OF USE THEREOF | TrueBinding, Inc. (US) | 2026-01-28 | — | — | EP | claimed |
| CN-1242704-A | Tabletted prepn. | AJINOMOTO KK (JP) | 2000-01-26 | — | — | CN | claimed |
| EP-0965339-A1 | TABLETTED PREPARATION | Ajinomoto Co., Inc. (JP) | 1999-12-22 | — | — | EP | claimed |
| WO-1998056378-A1 | NOVEL NIDDM REGIMEN | NOVO NORDISK A/S (DK) | 1998-12-17 | — | — | WO | claimed |
| EP-0526171-B1 | Crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and methods for preparing them | AJINOMOTO KK (JP) | 1997-03-05 | — | — | EP | claimed |
| US-5488150-A | ANTIDIABETIC AGENTS OR HYPOGLYCEMIC AGENTS | AJINOMOTO CO., INC. (JP) | 1996-01-30 | — | — | US | claimed |
| US-5463116-A | Stable crystals having specified melting point, powder X-ray diffraction pattern and/or infrared absorption spectrum | AJINOMOTO CO., INC. (JP) | 1995-10-31 | — | — | US | claimed |
| US-RE34878-E | Hypoglycemic agent | AJINOMOTO CO., INC. (JP) | 1995-03-14 | — | — | US | claimed |
| EP-0526171-A2 | Crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and methods for preparing them | Ajinomoto Co., Inc. (JP) | 1993-02-03 | — | — | EP | claimed |
| EP-0196222-B1 | HYPOGLYCEMIC AGENT | AJINOMOTO CO., INC. (JP) | 1992-01-29 | — | — | EP | claimed |
| US-4816484-A | D-PHENYLALANINE DERIVATIVES | AJINOMOTO CO., INC. (JP) | 1989-03-28 | — | — | US | claimed |