Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.55 |
| ▸ | AVPR1B | P47901 | 3/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1381004 | 0.85 | HRH3 (0.65) | HRH3AVPR1BPDE3BPDE3A | |
| SCHEMBL2209226 | 0.85 | HRH3 (0.51) | HRH3AVPR1BPDE3BPDE3A | |
| SCHEMBL2211945 | 0.82 | HRH3 (0.54) | HRH3AVPR1B | |
| SCHEMBL2209034 | 0.81 | HRH3 (0.52) | HRH3PDE3BPDE3ATLR9TLR7 | |
| SCHEMBL2211880 | 0.80 | HRH3 (0.51) | HRH3AVPR1BPDE3BPDE3AMAOB | |
| SCHEMBL4501875 | 0.80 | HRH3 (0.63) | HRH3AVPR1BMAOB | |
| SCHEMBL2208812 | 0.77 | HRH3 (0.54) | HRH3AVPR1BMAOBSCN7A | |
| SCHEMBL2242065 | 0.77 | HRH3 (0.57) | HRH3 | |
| SCHEMBL4490636 | 0.77 | HRH3 (0.64) | HRH3AVPR1BMAOB | |
| SCHEMBL2212122 | 0.76 | HRH3 (0.51) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805166-B1 | QUINOLINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-07-27 | — | — | EP | claimed |