Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | SHBG | P04278 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22088759 | 1.00 | STS (0.58) | STSKDM4EALDH1A1HSD17B1LMNA | |
| SCHEMBL4893106 | 0.91 | STS (0.69) | STSKDM4EALDH1A1HSD17B1LMNA | |
| SCHEMBL4893115 | 0.91 | STS (0.69) | STSKDM4EALDH1A1HSD17B1LMNA | |
| SCHEMBL22088767 | 0.89 | STS (0.47) | STSKDM4EALDH1A1HSD17B1LMNA | |
| SCHEMBL22088765 | 0.89 | STS (0.47) | STSKDM4EALDH1A1HSD17B1LMNA | |
| SCHEMBL22236691 | 0.89 | STS (0.47) | STSKDM4EALDH1A1HSD17B1LMNA | |
| SCHEMBL22089406 | 0.89 | STS (0.47) | STSKDM4EALDH1A1HSD17B1LMNA | |
| SCHEMBL22088749 | 0.89 | STS (0.59) | STSKDM4EALDH1A1HSD17B1LMNA | |
| SCHEMBL22089284 | 0.89 | STS (0.59) | STSKDM4EALDH1A1HSD17B1LMNA | |
| SCHEMBL22089087 | 0.88 | HRH3 (0.49) | STSKDM4EALDH1A1HSD17B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3634975-B1 | 17-OXIMES OF 15.BETA.-[3-PROPANAMIDO]-SUBSTITUTED ESTRA-1,3,5(10)-TRIEN-17-ONES FOR USE IN INHIBITION OF 17.BETA.-HYDROXYSTEROID DEHYDROGENASES | ORGANON R&D FINLAND LTD (FI) | 2024-02-28 | — | — | EP | disclosed |
| US-20220127303-A1 | THERAPEUTICALLY ACTIVE STEROIDAL DERIVATIVES | FORENDO PHARMA LTD (FI) | 2022-04-28 | — | — | US | disclosed |
| US-11254703-B2 | Therapeutically active steroidal derivatives | FORENDO PHARMA LTD (FI) | 2022-02-22 | — | — | US | disclosed |
| US-20200317718-A1 | THERAPEUTICALLY ACTIVE STEROIDAL DERIVATIVES | FORENDO PHARMA LTD (FI) | 2020-10-08 | — | — | US | disclosed |
| US-10717761-B2 | Therapeutically active steroidal derivatives | FORENDO PHARMA LTD (FI) | 2020-07-21 | — | — | US | disclosed |
| WO-2020115371-A1 | ESTRA-1,3,5(10)-TRIENE COMPOUNDS CONDENSED IN POSITION 16(17) WITH A PYRAZOLE RING AS INHIBITORS OF 17-HSD1 | FORENDO PHARMA LTD (FI) | 2020-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220127303-A1 | THERAPEUTICALLY ACTIVE STEROIDAL DERIVATIVES | HSD17B11, NR5A1, CYP17A1 | STS 39/4885KDM4E 1421/4885ALDH1A1 144/4885 |
| US-11254703-B2 | Therapeutically active steroidal derivatives | HSD17B11, NR5A1, CYP17A1 | STS 38/4885KDM4E 1553/4885ALDH1A1 151/4885 |
| US-20200317718-A1 | THERAPEUTICALLY ACTIVE STEROIDAL DERIVATIVES | HSD17B11, NR5A1, CYP17A1 | STS 38/4885KDM4E 1553/4885ALDH1A1 151/4885 |
| US-10717761-B2 | Therapeutically active steroidal derivatives | HSD17B11, NR5A1, CYP17A1 | STS 36/4885KDM4E 1654/4885ALDH1A1 150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.