Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | STS | P08842 | 4/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | SHBG | P04278 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22089301 | 0.88 | HRH3 (0.46) | HRH3KCNH2STSHSD17B1AKR1C3 | |
| SCHEMBL4886059 | 0.88 | STS (0.55) | HRH3KCNH2STSHSD17B1AKR1B10 | |
| SCHEMBL4886055 | 0.88 | STS (0.55) | HRH3KCNH2STSHSD17B1AKR1B10 | |
| SCHEMBL22088759 | 0.88 | STS (0.58) | HRH3STSHSD17B1AKR1B10LMNA | |
| SCHEMBL22089407 | 0.88 | STS (0.58) | HRH3STSHSD17B1AKR1B10LMNA | |
| SCHEMBL22088765 | 0.85 | STS (0.47) | HRH3KCNH2STSHSD17B1AKR1B10 | |
| SCHEMBL22236691 | 0.85 | STS (0.47) | HRH3KCNH2STSHSD17B1AKR1B10 | |
| SCHEMBL22089406 | 0.85 | STS (0.47) | HRH3KCNH2STSHSD17B1AKR1B10 | |
| SCHEMBL22088767 | 0.85 | STS (0.47) | HRH3KCNH2STSHSD17B1AKR1B10 | |
| SCHEMBL20579093 | 0.85 | HRH3 (0.40) | HRH3KCNH2STSCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3891167-B1 | ESTRA-1,3,5(10)-TRIENE COMPOUNDS CONDENSED IN POSITION 16(17) WITH A PYRAZOLE RING AS INHIBITORS OF 17-HSD1 | Organon R&D Finland Oy (FI) | 2024-11-13 | — | — | EP | disclosed |
| US-20220041647-A1 | ESTRA-1,3,5(10)-TRIENE COMPOUNDS CONDENSED IN POSITION 16(17) WITH A PYRAZOLE RING AS INHIBITORS OF 17-HSD1 | FORENDO PHARMA LTD. (FI) | 2022-02-10 | — | — | US | disclosed |
| CN-113412269-A | Estra-1, 3,5(10) -trienes having a condensed pyrazole ring in position 16(17) as 17-HSD1 inhibitors | 佛恩多制药有限公司 | 2021-09-17 | — | — | CN | disclosed |
| WO-2020115371-A1 | ESTRA-1,3,5(10)-TRIENE COMPOUNDS CONDENSED IN POSITION 16(17) WITH A PYRAZOLE RING AS INHIBITORS OF 17-HSD1 | FORENDO PHARMA LTD (FI) | 2020-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220041647-A1 | ESTRA-1,3,5(10)-TRIENE COMPOUNDS CONDENSED IN POSITION 16(17) WITH A PYRAZOLE RING AS INHIBITORS OF 17-HSD1 | HSD17B11, CYP19A1, HSD17B1 | HRH3 1297/4885KCNH2 2874/4885STS 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.