Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 15/20 | 0.71 |
| ▸ | KDR | P35968 | 15/20 | 0.71 |
| ▸ | MET | P08581 | 4/20 | 0.66 |
| ▸ | KIT | P10721 | 3/20 | 0.64 |
| ▸ | AXL | P30530 | 2/20 | 0.64 |
| ▸ | RET | P07949 | 2/20 | 0.64 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.64 |
| ▸ | AURKA | O14965 | 1/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.64 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
| ▸ | PGR | P06401 | 1/20 | 0.64 |
| ▸ | LYN | P07948 | 1/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.64 |
| ▸ | HCK | P08631 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371648 | 0.87 | PDGFRA (0.84) | PDGFRAKDRMETKITAXL | |
| SCHEMBL1878918 | 0.87 | KDR (0.83) | PDGFRAKDRMETKITAXL | |
| SCHEMBL22104149 | 0.85 | PDGFRA (0.73) | PDGFRAKDRMETKITAXL | |
| SCHEMBL1880338 | 0.85 | KDR (0.80) | PDGFRAKDRMETKITAXL | |
| SCHEMBL1875329 | 0.85 | PDGFRA (0.72) | PDGFRAKDRMETAXLFLT3 | |
| SCHEMBL22104179 | 0.85 | PDGFRA (0.73) | PDGFRAKDRMETKITAXL | |
| SCHEMBL24142383 | 0.85 | PDGFRA (0.79) | PDGFRAKDRMETKITAXL | |
| SCHEMBL5824367 | 0.85 | PDGFRA (0.79) | PDGFRAKDRMETKITAXL | |
| SCHEMBL22104155 | 0.84 | PDGFRA (0.74) | PDGFRAKDRMETKITAXL | |
| SCHEMBL1878889 | 0.84 | PDGFRA (0.73) | PDGFRAKDRMETKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12404244-B2 | Pan-KIT kinase inhibitor having quinoline structure and application thereof | Tarapeutics Science Inc. (CN) | 2025-09-02 | — | — | US | disclosed |
| US-20250186452-A1 | NOVEL USE OF QUINOLINE COMPOUND | Tarapeutics Science Inc. (CN) | 2025-06-12 | — | — | US | disclosed |
| EP-4491181-A1 | NOVEL USE OF QUINOLINE COMPOUND | Tarapeutics Science Inc. (CN) | 2025-01-15 | — | — | EP | disclosed |
| EP-3896059-B1 | PAN-KIT KINASE INHIBITOR HAVING QUINOLINE STRUCTURE AND APPLICATION THEREOF | TARAPEUTICS SCIENCE INC (CN) | 2024-01-10 | — | — | EP | disclosed |
| CN-116763787-A | New application of quinoline compound | 安徽中科拓苒药物科学研究有限公司 | 2023-09-19 | — | — | CN | disclosed |
| WO-2023168740-A1 | NOVEL USE OF QUINOLINE COMPOUND | 安徽中科拓苒药物科学研究有限公司 | 2023-09-14 | — | — | WO | disclosed |
| WO-2023168740-A1 | NOVEL USE OF QUINOLINE COMPOUND | 安徽中科拓苒药物科学研究有限公司 | 2023-09-14 | — | — | WO | disclosed |
| CN-111303024-B | Quinoline-structured pan-KIT kinase inhibitor and application thereof | 安徽中科拓苒药物科学研究有限公司 | 2023-03-28 | — | — | CN | disclosed |
| US-20220064117-A1 | PAN-KIT KINASE INHIBITOR HAVING QUINOLINE STRUCTURE AND APPLICATION THEREOF | Tarapeutics Science Inc. (CN) | 2022-03-03 | — | — | US | disclosed |
| US-20220064117-A1 | PAN-KIT KINASE INHIBITOR HAVING QUINOLINE STRUCTURE AND APPLICATION THEREOF | Tarapeutics Science Inc. (CN) | 2022-03-03 | — | — | US | disclosed |
| EP-3896059-A1 | PAN-KIT KINASE INHIBITOR HAVING QUINOLINE STRUCTURE AND APPLICATION THEREOF | Tarapeutics Science Inc. (CN) | 2021-10-20 | — | — | EP | disclosed |
| EP-3896059-A1 | PAN-KIT KINASE INHIBITOR HAVING QUINOLINE STRUCTURE AND APPLICATION THEREOF | Tarapeutics Science Inc. (CN) | 2021-10-20 | — | — | EP | disclosed |
| CN-111303024-A | Quinoline-structured pan-KIT kinase inhibitor and application thereof | 安徽中科拓苒药物科学研究有限公司 | 2020-06-19 | — | — | CN | disclosed |
| WO-2020118753-A1 | PAN-KIT KINASE INHIBITOR HAVING QUINOLINE STRUCTURE AND APPLICATION THEREOF | 安徽中科拓苒药物科学研究有限公司 | 2020-06-18 | — | — | WO | disclosed |
| WO-2020118753-A1 | PAN-KIT KINASE INHIBITOR HAVING QUINOLINE STRUCTURE AND APPLICATION THEREOF | 安徽中科拓苒药物科学研究有限公司 | 2020-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12404244-B2 | Pan-KIT kinase inhibitor having quinoline structure and application thereof | KIT, MAP3K7, ABL1 | PDGFRA 747/4885KDR 357/4885MET 1150/4885 |
| US-20250186452-A1 | NOVEL USE OF QUINOLINE COMPOUND | ARG1, MSR1, SLC11A2 | PDGFRA 2224/4885KDR 1464/4885MET 747/4885 |
| US-20220064117-A1 | PAN-KIT KINASE INHIBITOR HAVING QUINOLINE STRUCTURE AND APPLICATION THEREOF | KIT, MAP3K7, ABL1 | PDGFRA 747/4885KDR 357/4885MET 1150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.