Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MET | P08581 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1007347 | 0.80 | SLC6A4 (0.56) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL6186358 | 0.79 | SLC6A4 (0.55) | KCNH2SLC6A2SLC6A4SLC6A3RAB9A | |
| Hydrochloric Acid SCHEMBL28021572 | 0.78 | CHKA (0.61) | CHKAKCNH2HRH3SLC6A2SLC6A4 | |
| SCHEMBL3314997 | 0.75 | IKBKB (0.48) | PIM1KDRCDK2 | |
| SCHEMBL17484487 | 0.74 | KCNJ1 (0.42) | KCNH2HRH3PIM1POLBRAB9A | |
| SCHEMBL18583354 | 0.72 | NPC1 (0.52) | CHKANPC1METKDRFLT1 | |
| SCHEMBL28879884 | 0.72 | MAPT (0.53) | CHKANPC1METDAOPOLB | |
| SCHEMBL3005405 | 0.72 | ALDH1A1 (0.53) | CHKAKCNH2HRH3NPC1MET | |
| SCHEMBL21460236 | 0.72 | MEN1 (0.47) | CHKANPC1POLB | |
| SCHEMBL31307735 | 0.72 | SLC6A2 (0.56) | KCNH2SLC6A2SLC6A4SLC6A3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3894396-A1 | 2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS | Ideaya Biosciences, Inc. (US) | 2021-10-20 | — | — | EP | disclosed |
| WO-2020123395-A1 | 2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-06-18 | — | — | WO | disclosed |