Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.42 |
| ▸ | OPA1 | O60313 | 1/20 | 0.40 |
| ▸ | EIF5B | O60841 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20365440 | 0.84 | HTR2A (0.54) | HTR2AHTR2CALDH1A1HPGDUSP2 | |
| SCHEMBL23221087 | 0.79 | HPGD (0.55) | HTR2AHTR2CALDH1A1HPGDUSP2 | |
| SCHEMBL25030544 | 0.78 | MEN1 (0.42) | HTR2AHTR2CALDH1A1HPGDUSP2 | |
| SCHEMBL17553683 | 0.76 | HTR2A (0.54) | HTR2AHTR2CALDH1A1HPGDUSP2 | |
| SCHEMBL23691134 | 0.76 | HTR2A (0.55) | HTR2AHTR2CALDH1A1HPGDUSP2 | |
| SCHEMBL26370481 | 0.74 | HPGD (0.46) | HTR2AHTR2CALDH1A1HPGDUSP2 | |
| SCHEMBL9559917 | 0.71 | PIM1 (0.56) | HTR2AHTR2CALDH1A1HPGDUSP2 | |
| SCHEMBL10100276 | 0.71 | HTR2A (0.59) | HTR2AHTR2CALDH1A1HPGDUSP2 | |
| SCHEMBL8039755 | 0.71 | HTR2A (0.49) | HTR2AHTR2CALDH1A1HPGDUSP2 | |
| SCHEMBL2261530 | 0.70 | HTR2A (0.48) | HTR2AHTR2CMTNR1AMTNR1BMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10683278-B2 | Substituted quinolone derivatives, or pharmaceutically acceptable salts or stereoisomers thereof, and pharmaceutical compositions and use thereof | SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. (CN) | 2020-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10683278-B2 | Substituted quinolone derivatives, or pharmaceutically acceptable salts or stereoisomers thereof, and pharmaceutical compositions and use thereof | NRAS, AXL, ABL1 | HTR2A 4274/4885HTR2C 4112/4885ALDH1A1 3691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.