Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 13/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4327643 | 0.81 | HDAC1 (0.67) | HDAC1HDAC2HDAC3 | |
| SCHEMBL4310940 | 0.81 | HDAC2 (0.70) | HDAC1HDAC2HDAC3 | |
| SCHEMBL4318379 | 0.79 | HDAC1 (0.70) | HDAC1HDAC2HDAC3 | |
| SCHEMBL2209878 | 0.79 | HDAC1 (0.62) | HDAC1HDAC2HDAC3 | |
| SCHEMBL2211311 | 0.79 | HDAC1 (0.66) | HDAC1HDAC2HDAC3 | |
| SCHEMBL16380794 | 0.79 | HDAC2 (1.00) | HDAC1HDAC2HDAC3 | |
| SCHEMBL996208 | 0.79 | CYP2C9 (0.42) | HDAC1HDAC2HDAC3 | |
| SCHEMBL26775695 | 0.78 | HDAC2 (0.86) | HDAC1HDAC2HDAC3 | |
| SCHEMBL4310937 | 0.78 | HDAC2 (0.71) | HDAC1HDAC2HDAC3 | |
| SCHEMBL18653510 | 0.78 | HDAC1 (0.73) | HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981874-B2 | Phosphorus derivatives as histone deacetylase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2011-07-19 | — | — | US | disclosed |