Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4327649 | 0.93 | HDAC1 (0.67) | HDAC1HDAC2HDAC3 | |
| SCHEMBL4318379 | 0.86 | HDAC1 (0.70) | HDAC1HDAC2HDAC3 | |
| SCHEMBL3642625 | 0.85 | HDAC1 (0.75) | HDAC1HDAC2HDAC3 | |
| SCHEMBL4322080 | 0.84 | HDAC1 (0.67) | HDAC1HDAC2HDAC3 | |
| SCHEMBL2206492 | 0.84 | HDAC1 (0.69) | HDAC1HDAC2HDAC3 | |
| SCHEMBL4310940 | 0.84 | HDAC2 (0.70) | HDAC1HDAC2HDAC3 | |
| SCHEMBL4580508 | 0.83 | HDAC1 (0.77) | HDAC1HDAC2HDAC3 | |
| SCHEMBL26775695 | 0.83 | HDAC2 (0.86) | HDAC1HDAC2HDAC3 | |
| SCHEMBL4581182 | 0.81 | HDAC2 (0.83) | HDAC1HDAC2HDAC3 | |
| SCHEMBL2209644 | 0.81 | HDAC1 (0.62) | HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270351-A1 | PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270351-A1 | PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | HDAC5, PPM1A, PTEN | HDAC1 4/4885HDAC2 8/4885HDAC3 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.