Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.60 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.60 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.60 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.54 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.50 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.50 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | GUSB | P08236 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22096478 | 1.00 | S1PR1 (0.60) | S1PR1S1PR3S1PR5S1PR4GNAI3 | |
| SCHEMBL19606301 | 1.00 | S1PR1 (0.60) | S1PR1S1PR3S1PR5S1PR4GNAI3 | |
| SCHEMBL23168673 | 0.89 | S1PR1 (0.59) | S1PR1S1PR3S1PR5S1PR4GNAI3 | |
| SCHEMBL20858257 | 0.83 | S1PR1 (0.54) | S1PR1S1PR3S1PR5S1PR4GNAI3 | |
| SCHEMBL4550235 | 0.83 | KDM4E (0.43) | S1PR1S1PR3S1PR5S1PR4SIGMAR1 | |
| SCHEMBL19604907 | 0.82 | S1PR1 (0.42) | S1PR1S1PR3S1PR5S1PR4GNAI3 | |
| SCHEMBL24179174 | 0.81 | S1PR1 (0.51) | S1PR1S1PR3S1PR5S1PR4GNAI3 | |
| SCHEMBL19710571 | 0.81 | S1PR1 (0.57) | S1PR1S1PR3S1PR5S1PR4GNAI3 | |
| SCHEMBL19604912 | 0.80 | S1PR1 (0.51) | S1PR1S1PR3S1PR5S1PR4GNAI3 | |
| SCHEMBL26748967 | 0.79 | S1PR1 (0.44) | S1PR1S1PR3S1PR5S1PR4GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12018017-B2 | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2024-06-25 | — | — | US | disclosed |
| US-20230174515-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF | ENANTA PHARM INC (US) | 2023-06-08 | — | — | US | disclosed |
| US-11560368-B2 | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2023-01-24 | — | — | US | disclosed |
| US-10683279-B2 | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2020-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11560368-B2 | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof | BAD, CASP1, BAX | S1PR1 462/4885S1PR3 747/4885S1PR5 860/4885 |
| US-12018017-B2 | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof | BAD, CASP1, BAX | S1PR1 462/4885S1PR3 747/4885S1PR5 860/4885 |
| US-10683279-B2 | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof | BAD, CASP1, BAX | S1PR1 462/4885S1PR3 747/4885S1PR5 860/4885 |
| US-20230174515-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF | BAD, CASP1, BAX | S1PR1 462/4885S1PR3 747/4885S1PR5 860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.