Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 5/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27064927 | 0.94 | IGF1R (0.48) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL27059362 | 0.91 | IGF1R (0.53) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL27064719 | 0.86 | IGF1R (0.44) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL28606139 | 0.86 | IGF1R (0.45) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL24853389 | 0.84 | IGF1R (0.52) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL27059360 | 0.84 | IGF1R (0.53) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL31557690 | 0.84 | IGF1R (0.53) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL24852749 | 0.83 | FLT4 (0.53) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL30956471 | 0.83 | IGF1R (0.41) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL27059309 | 0.83 | IGF1R (0.48) | IGF1RCDK1CDK2CDK8CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020119819-A1 | BENZAMIDES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2020-06-18 | — | — | WO | disclosed |