Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30956471 | 0.90 | IGF1R (0.41) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL27059362 | 0.89 | IGF1R (0.53) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL22098023 | 0.86 | IGF1R (0.48) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL28716455 | 0.85 | IGF1R (0.41) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL27059360 | 0.83 | IGF1R (0.53) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL31557690 | 0.83 | IGF1R (0.53) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL30956580 | 0.82 | CPT1A (0.39) | IGF1RJAK3JAK2JAK1 | |
| SCHEMBL27059309 | 0.81 | IGF1R (0.48) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL24853389 | 0.81 | IGF1R (0.52) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL24852749 | 0.81 | FLT4 (0.53) | IGF1RCDK1CDK2CDK8CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-113227074-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods | 凌科药业(杭州)有限公司 | 2021-08-06 | — | — | CN | disclosed |