Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24766843 | 1.00 | MEN1 (0.46) | MEN1KMT2AKCNA5NPC1RAB9A | |
| SCHEMBL14085934 | 0.84 | MEN1 (0.43) | MEN1KMT2AKCNA5NPC1RAB9A | |
| SCHEMBL9131611 | 0.84 | MEN1 (0.47) | MEN1KMT2ANPC1RAB9ARORC | |
| SCHEMBL3450837 | 0.82 | MEN1 (0.41) | MEN1KMT2AKCNA5NPC1RAB9A | |
| SCHEMBL3450839 | 0.82 | MEN1 (0.41) | MEN1KMT2AKCNA5NPC1RAB9A | |
| SCHEMBL14085943 | 0.80 | MEN1 (0.40) | MEN1KMT2AKCNA5NPC1RAB9A | |
| SCHEMBL21480168 | 0.79 | KDM4E (0.46) | MEN1KMT2ARORCHDAC3HDAC1 | |
| SCHEMBL10509525 | 0.79 | NPC1 (0.51) | MEN1KMT2AKCNA5NPC1RAB9A | |
| SCHEMBL3364898 | 0.79 | NPC1 (0.52) | MEN1KMT2ANPC1RAB9AHDAC3 | |
| SCHEMBL6321619 | 0.78 | MEN1 (0.49) | MEN1KMT2AKCNA5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3894416-B1 | FERROPORTIN INHIBITORS AND METHODS OF USE | GLOBAL BLOOD THERAPEUTICS INC (US) | 2022-11-09 | — | — | EP | disclosed |
| WO-2020123850-A1 | FERROPORTIN INHIBITORS AND METHODS OF USE | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2020-06-18 | — | — | WO | disclosed |