Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.44 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.44 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930458 | 0.85 | PLK1 (0.51) | PLK1HSD17B1HSD17B2GAAKDM4E | |
| SCHEMBL3930459 | 0.85 | PLK1 (0.51) | PLK1HSD17B1HSD17B2GAAKDM4E | |
| SCHEMBL3937664 | 0.84 | PLK1 (0.50) | PLK1HSD17B1HSD17B2GAAKDM4E | |
| SCHEMBL20145771 | 0.84 | PLK1 (0.50) | PLK1HSD17B1HSD17B2GAAKDM4E | |
| SCHEMBL29581270 | 0.83 | CA1 (0.47) | GAAKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL1096840 | 0.83 | CA1 (0.47) | GAAKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL14288600 | 0.83 | PLK1 (0.54) | PLK1HSD17B1HSD17B2GAAKDM4E | |
| SCHEMBL7959771 | 0.82 | PLK1 (0.64) | PLK1HSD17B1HSD17B2GAAKDM4E | |
| SCHEMBL89288 | 0.82 | NPC1 (0.56) | GAAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL5270681 | 0.81 | CA1 (0.47) | KDM4ELMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321261-B1 | HEDGEHOG ANTAGONISTS HAVING ZINC BINDING MOIETIES | CURIS INC (US) | 2020-06-17 | — | — | EP | disclosed |