Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930459 | 0.85 | PLK1 (0.51) | PLK1HSD17B1HSD17B2GAAKDM4E | |
| SCHEMBL3930458 | 0.85 | PLK1 (0.51) | PLK1HSD17B1HSD17B2GAAKDM4E | |
| SCHEMBL22100726 | 0.84 | PLK1 (0.50) | PLK1HSD17B1HSD17B2GAAKDM4E | |
| SCHEMBL3937664 | 0.84 | PLK1 (0.50) | PLK1HSD17B1HSD17B2GAAKDM4E | |
| SCHEMBL14288600 | 0.83 | PLK1 (0.54) | PLK1HSD17B1HSD17B2GAAKDM4E | |
| SCHEMBL7959771 | 0.82 | PLK1 (0.64) | PLK1HSD17B1HSD17B2GAAKDM4E | |
| SCHEMBL1911352 | 0.82 | NPC1 (0.56) | GAAKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL3940442 | 0.80 | GAA (0.51) | PLK1HSD17B1HSD17B2GAAKDM4E | |
| SCHEMBL17414596 | 0.78 | PLK1 (0.55) | PLK1HSD17B1HSD17B2GAAKDM4E | |
| SCHEMBL12430522 | 0.76 | PLK1 (0.56) | PLK1HSD17B1HSD17B2GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321261-A1 | HEDGEHOG ANTAGONISTS HAVING ZINC BINDING MOIETIES | Curis, Inc. (US) | 2018-05-16 | — | — | EP | disclosed |