Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30291451 | 1.00 | TSHR (0.33) | TSHR | |
| SCHEMBL1338928 | 0.86 | KDM4E (0.31) | — | |
| SCHEMBL5326358 | 0.83 | — | — | |
| SCHEMBL19309616 | 0.82 | TSHR (0.46) | TSHR | |
| SCHEMBL20859051 | 0.79 | TSHR (0.48) | TSHR | |
| SCHEMBL22995757 | 0.77 | TSHR (0.46) | TSHR | |
| SCHEMBL16985345 | 0.75 | — | — | |
| SCHEMBL20869261 | 0.74 | TSHR (0.42) | TSHR | |
| SCHEMBL337849 | 0.74 | APLNR (0.33) | — | |
| SCHEMBL12886442 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3738954-A1 | METHOD OF PREPARATION OF SUBSTITUTED 2,4-DIAMINO-PYRIMIDINE-5-CARBOXAMIDES | Signal Pharmaceuticals, LLC (US) | 2020-11-18 | — | — | EP | disclosed |
| EP-3099302-B1 | CRYSTALLINE FORMS OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE | SIGNAL PHARM LLC (US) | 2020-06-17 | — | — | EP | disclosed |