Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | FECH | P22830 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminoserine SCHEMBL2208123 | 1.00 | PLK1 (0.40) | PLK1HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL2210635 | 0.88 | PLK1 (0.37) | PLK1HDAC1HDAC4HDAC3HDAC7 | |
| Hydrochloric Acid SCHEMBL2212790 | 0.87 | PLK1 (0.38) | PLK1HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL30527938 | 0.87 | ALDH1A1 (0.47) | PLK1HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL826254 | 0.87 | ALDH1A1 (0.47) | PLK1HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL826253 | 0.87 | ALDH1A1 (0.47) | PLK1HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL1635152 | 0.85 | PLK1 (0.41) | PLK1HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL1635155 | 0.85 | PLK1 (0.41) | PLK1HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL4891286 | 0.85 | PLK1 (0.41) | PLK1HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL1635890 | 0.85 | PLK1 (0.41) | PLK1HDAC1HDAC4HDAC3HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534284-B1 | AMINO-SUBSTITUTED SULFONANILIDES AND DERIVATIVES THEREOF FOR TREATING PROLIFERATIVE DISORDERS | UNIV TEMPLE (US) | 2011-07-27 | — | — | EP | claimed |
| US-7161031-B2 | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2007-01-09 | — | — | US | claimed |
| US-20050096484-A1 | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders | ONCONOVA THERAPEUTICS, INC. | 2005-05-05 | — | — | US | claimed |
| EP-1534284-B1 | AMINO-SUBSTITUTED SULFONANILIDES AND DERIVATIVES THEREOF FOR TREATING PROLIFERATIVE DISORDERS | UNIV TEMPLE (US) | 2011-07-27 | — | — | EP | disclosed |
| US-7161031-B2 | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2007-01-09 | — | — | US | disclosed |
| EP-1534284-A4 | AMINO-SUBSTITUTED SULFONANILIDES AND DERIVATIVES THEREOF FOR TREATING PROLIFERATIVE DISORDERS | UNIV TEMPLE (US) | 2006-08-16 | — | — | EP | disclosed |
| EP-1534284-A2 | AMINO-SUBSTITUTED SULFONANILIDES AND DERIVATIVES THEREOF FOR TREATING PROLIFERATIVE DISORDERS | Temple University of the Commonwealth System of Higher Education (US) | 2005-06-01 | — | — | EP | disclosed |
| US-20050096484-A1 | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders | ONCONOVA THERAPEUTICS, INC. | 2005-05-05 | — | — | US | disclosed |
| WO-2003072063-A2 | AMINO-SUBSTITUTED SULFONANILIDES AND DERIVATIVES THEREOF FOR TREATING PROLIFERATIVE DISORDERS | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2003-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096484-A1 | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders | ARSA, MKI67, CCNA1 | PLK1 690/4885HDAC1 1137/4885HDAC4 2120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.