Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | GMNN | O75496 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PAM | P19021 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL592448 | 1.00 | LMNA (0.66) | LMNAMAPK1MAPTGMNNNPSR1 | |
| SCHEMBL26877916 | 0.90 | LMNA (0.77) | LMNAMAPK1MAPTGMNNNPSR1 | |
| SCHEMBL25867942 | 0.90 | LMNA (0.77) | LMNAMAPK1MAPTGMNNNPSR1 | |
| SCHEMBL25867943 | 0.90 | LMNA (0.77) | LMNAMAPK1MAPTGMNNNPSR1 | |
| SCHEMBL25867947 | 0.90 | LMNA (0.77) | LMNAMAPK1MAPTGMNNNPSR1 | |
| SCHEMBL25867938 | 0.90 | LMNA (0.77) | LMNAMAPK1MAPTGMNNNPSR1 | |
| SCHEMBL25867941 | 0.90 | LMNA (0.77) | LMNAMAPK1MAPTGMNNNPSR1 | |
| SCHEMBL25867945 | 0.90 | LMNA (0.77) | LMNAMAPK1MAPTGMNNNPSR1 | |
| SCHEMBL26877920 | 0.90 | LMNA (0.77) | LMNAMAPK1MAPTGMNNNPSR1 | |
| SCHEMBL25867940 | 0.90 | LMNA (0.77) | LMNAMAPK1MAPTGMNNNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981899-B2 | Skin aging resistance, wrinkling resistance; (S)-1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid | MERCK PATENT GMBH (DE) | 2011-07-19 | — | — | US | disclosed |