Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 8/20 | 0.38 |
| ▸ | FLT3 | P36888 | 4/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19145729 | 0.88 | DAO (0.47) | CDK5CDK5R1DAOKDM4ENPC1 | |
| SCHEMBL19145552 | 0.86 | KDR (0.48) | CDK5CDK5R1DAOKDM4ENPC1 | |
| SCHEMBL19127012 | 0.85 | MAPK14 (0.46) | CDK5CDK5R1DAOKDM4ENPC1 | |
| SCHEMBL19127082 | 0.84 | KDM4E (0.43) | CDK5CDK5R1DAOKDM4ENPC1 | |
| SCHEMBL19126504 | 0.83 | CDK5 (0.43) | CDK5CDK5R1DAOKDM4ENPC1 | |
| SCHEMBL19126535 | 0.83 | ALDH1A1 (0.47) | CDK5CDK5R1KDM4ENPC1ALDH1A1 | |
| SCHEMBL30810529 | 0.83 | CDK5 (0.43) | CDK5CDK5R1DAOKDM4ENPC1 | |
| SCHEMBL19127238 | 0.82 | DHODH (0.47) | CDK5CDK5R1DAOKDM4ENPC1 | |
| SCHEMBL19126803 | 0.82 | KDM4E (0.41) | CDK5CDK5R1DAOKDM4ENPC1 | |
| SCHEMBL19146104 | 0.82 | KDR (0.42) | CDK5CDK5R1DAOKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11174241-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2021-11-16 | — | — | US | disclosed |
| US-20200190055-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11174241-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | CDK5 243/4885CDK5R1 269/4885DAO 3826/4885 |
| US-20200190055-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | CDK5 243/4885CDK5R1 269/4885DAO 3826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.