Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 10/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10436383 | 0.81 | FGFR1 (0.43) | FGFR1SLC22A6EP300MAPTPDE3A | |
| SCHEMBL18687280 | 0.80 | FGFR1 (0.42) | FGFR1SLC22A6EP300MAPTPDE3A | |
| SCHEMBL20117260 | 0.77 | FGFR1 (0.40) | FGFR1SLC22A6EP300MAPTLMNA | |
| SCHEMBL10436367 | 0.77 | FGFR1 (0.42) | FGFR1SLC22A6EP300MAPTPDE4D | |
| SCHEMBL18687555 | 0.76 | FGFR1 (0.39) | FGFR1SLC22A6EP300MAPTLMNA | |
| SCHEMBL10436523 | 0.75 | FGFR1 (0.43) | FGFR1SLC22A6EP300MAPTPDE4D | |
| SCHEMBL19590385 | 0.75 | FGFR1 (0.35) | FGFR1SLC22A6MAPTPDE4DPDE3A | |
| SCHEMBL2152990 | 0.74 | FGFR1 (0.52) | FGFR1SLC22A6EP300MAPTLMNA | |
| SCHEMBL19493433 | 0.74 | FGFR1 (0.52) | FGFR1SLC22A6EP300MAPTLMNA | |
| SCHEMBL19993637 | 0.73 | FGFR1 (0.36) | FGFR1SLC22A6MAPTPDE4DPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3183261-B1 | 2'-CHLORO AMINOPYRIMIDINONE AND PYRIMIDINE DIONE NUCLEOSIDES | GILEAD SCIENCES INC (US) | 2020-06-17 | — | — | EP | disclosed |