SCHEMBL22112385

SCHEMBL22112385

c1ccc(-c2ccc(N(c3ccc(-c4ccccc4)cc3)c3cc(-c4nc(-c5ccccc5)nc(-c5ccc6ccccc6c5)n4)cc4oc5ccccc5c34)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.38
KDM4E B2RXH2 3/20 0.38
ALDH1A1 P00352 3/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
KMT2A Q03164 2/20 0.38
MEN1 O00255 1/20 0.38
TP53 P04637 1/20 0.38
HSD17B10 Q99714 1/20 0.38
CCR4 P51679 1/20 0.34
TSHR P16473 3/20 0.32
POLB P06746 2/20 0.32
KDM1A O60341 1/20 0.32
MAPT P10636 3/20 0.32
LMNA P02545 2/20 0.32
TERT O14746 2/20 0.32
NOTUM Q6P988 1/20 0.32
GLA P06280 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24066167 0.99 KDM4E (0.37) CYP1A2KDM4EALDH1A1SMN1; SMN2KMT2A
SCHEMBL24899530 0.97 KDM4E (0.34) CYP1A2KDM4EALDH1A1SMN1; SMN2KMT2A
SCHEMBL22112395 0.94 TSHR (0.35) CYP1A2KDM4EALDH1A1SMN1; SMN2KMT2A
SCHEMBL22112392 0.94 TSHR (0.35) CYP1A2KDM4EALDH1A1SMN1; SMN2KMT2A
SCHEMBL22112381 0.94 TSHR (0.35) CYP1A2KDM4EALDH1A1SMN1; SMN2KMT2A
SCHEMBL22112382 0.94 TSHR (0.35) CYP1A2KDM4EALDH1A1SMN1; SMN2KMT2A
SCHEMBL24255633 0.93 CYP1A2 (0.33) CYP1A2KDM4EALDH1A1SMN1; SMN2KMT2A
SCHEMBL24899529 0.93 KDM4E (0.34) CYP1A2KDM4EALDH1A1SMN1; SMN2KMT2A
SCHEMBL24066137 0.93 ALDH1A1 (0.34) CYP1A2KDM4EALDH1A1SMN1; SMN2KMT2A
SCHEMBL24255636 0.92 ALDH1A1 (0.35) CYP1A2KDM4EALDH1A1SMN1; SMN2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020122576-A1 HETEROCYCLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE COMPRISING SAME, METHOD FOR MANUFACTURING SAME, AND COMPOSITION FOR ORGANIC MATERIAL LAYER 엘티소재주식회사 2020-06-18 WO disclosed