⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14090665 | 0.81 | HRH3 (0.32) | — | |
| SCHEMBL13656345 | 0.77 | HRH3 (0.40) | — | |
| SCHEMBL10032107 | 0.77 | HRH3 (0.40) | — | |
| SCHEMBL2928744 | 0.76 | FUCA1 (0.31) | — | |
| SCHEMBL2928741 | 0.76 | FUCA1 (0.31) | — | |
| SCHEMBL24812981 | 0.76 | FUCA1 (0.31) | — | |
| SCHEMBL23376017 | 0.75 | — | — | |
| SCHEMBL4463519 | 0.74 | ALOX15 (0.31) | — | |
| SCHEMBL18580080 | 0.74 | GBA1 (0.37) | — | |
| SCHEMBL92629 | 0.74 | FUCA1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3666774-B1 | 1H-PYRAZOLO[4,3-H]QUINAZOLINE COMPOUND SERVING AS PROTEIN KINASE INHIBITOR | SHENGKE PHARMACEUTICALS JIANGSU LTD (CN) | 2022-05-11 | — | — | EP | disclosed |
| EP-3666774-A1 | 1H-PYRAZOLO[4,3-H]QUINAZOLINE COMPOUND SERVING AS PROTEIN KINASE INHIBITOR | Shengke Pharmaceuticals (Jiangsu) Ltd. (CN) | 2020-06-17 | — | — | EP | disclosed |