Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.65 |
| ▸ | JAK3 | P52333 | 15/20 | 0.65 |
| ▸ | JAK1 | P23458 | 11/20 | 0.65 |
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.51 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.48 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.46 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22114667 | 0.94 | JAK2 (0.65) | JAK2JAK3JAK1CDK4CDK2 | |
| SCHEMBL22089802 | 0.91 | JAK3 (0.65) | JAK2JAK3JAK1MAP3K14IGF1R | |
| SCHEMBL29941749 | 0.91 | JAK3 (0.65) | JAK2JAK3JAK1MAP3K14IGF1R | |
| SCHEMBL22089900 | 0.91 | JAK2 (0.65) | JAK2JAK3JAK1CDK2IGF1R | |
| SCHEMBL22097940 | 0.90 | JAK2 (0.61) | JAK2JAK3JAK1CDK4CCNA2 | |
| SCHEMBL29942188 | 0.88 | CDK4 (0.54) | JAK2JAK3JAK1CDK4CCNA2 | |
| SCHEMBL22089701 | 0.88 | CDK4 (0.54) | JAK2JAK3JAK1CDK4CCNA2 | |
| SCHEMBL28600652 | 0.88 | CDK4 (0.54) | JAK2JAK3JAK1CDK4CCNA2 | |
| SCHEMBL22097751 | 0.88 | CDK4 (0.54) | JAK2JAK3JAK1CDK4CCNA2 | |
| SCHEMBL29942180 | 0.88 | CDK4 (0.54) | JAK2JAK3JAK1CDK4CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020118683-A1 | BENZAMIDES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2020-06-18 | — | — | WO | disclosed |