Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.54 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.54 |
| ▸ | EGFR | P00533 | 9/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | FES | P07332 | 1/20 | 0.44 |
| ▸ | FER | P16591 | 1/20 | 0.44 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.44 |
| ▸ | TEC | P42680 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22115113 | 0.91 | EGFR (0.52) | FGFR1FGFR4EGFRFGFR2FGFR3 | |
| SCHEMBL22115108 | 0.89 | FGFR4 (0.58) | FGFR1FGFR4EGFRFGFR2FGFR3 | |
| SCHEMBL22343344 | 0.84 | FGFR4 (0.56) | FGFR1FGFR4EGFRFGFR2FGFR3 | |
| SCHEMBL22114567 | 0.84 | FGFR4 (0.58) | FGFR1FGFR4EGFRFGFR2FGFR3 | |
| SCHEMBL22343228 | 0.83 | FGFR4 (0.56) | FGFR1FGFR4EGFRFGFR2FGFR3 | |
| SCHEMBL22114936 | 0.82 | FGFR4 (0.57) | FGFR1FGFR4EGFRFGFR2FGFR3 | |
| SCHEMBL22343074 | 0.82 | FGFR4 (0.55) | FGFR1FGFR4EGFRFGFR2FGFR3 | |
| SCHEMBL22343071 | 0.82 | EGFR (0.56) | FGFR1FGFR4EGFRFGFR2FGFR3 | |
| SCHEMBL22114817 | 0.81 | FGFR4 (0.52) | FGFR1FGFR4EGFRFGFR2FGFR3 | |
| SCHEMBL22343195 | 0.80 | FGFR4 (0.55) | FGFR1FGFR4EGFRFGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020119606-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR | GUANGDONG NEWOPP BIOPHARMACEUTICALS CO., LTD. (CN) | 2020-06-18 | — | — | WO | disclosed |