SCHEMBL22115294

SCHEMBL22115294

CCOC(=O)c1cc(C#N)c(=O)[nH]c1CCO

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 10/20 0.54
KMT2A Q03164 7/20 0.54
ALDH1A1 P00352 7/20 0.54
MEN1 O00255 4/20 0.54
RXFP1 Q9HBX9 2/20 0.54
KDM4E B2RXH2 10/20 0.53
GLA P06280 1/20 0.52
ATM Q13315 1/20 0.52
POLB P06746 3/20 0.52
LMNA P02545 2/20 0.52
HPGD P15428 2/20 0.52
NPSR1 Q6W5P4 1/20 0.51
HSD17B10 Q99714 3/20 0.48
GAA P10253 3/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
ALOX15 P16050 2/20 0.45
TP53 P04637 1/20 0.45
APOBEC3G Q9HC16 1/20 0.45
CASP1 P29466 1/20 0.44
NPC1 O15118 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26784496 0.91 KDM4E (0.56) MAPTKMT2AALDH1A1MEN1RXFP1
SCHEMBL22115166 0.90 MAPT (0.56) MAPTKMT2AALDH1A1MEN1RXFP1
SCHEMBL3939838 0.89 MAPT (0.53) MAPTKMT2AALDH1A1MEN1RXFP1
SCHEMBL4105396 0.88 MAPT (0.58) MAPTKMT2AALDH1A1MEN1RXFP1
SCHEMBL3327316 0.88 MAPT (0.52) MAPTKMT2AALDH1A1MEN1RXFP1
SCHEMBL3326985 0.86 MAPT (0.55) MAPTKMT2AALDH1A1MEN1RXFP1
SCHEMBL3587530 0.86 MAPT (0.55) MAPTKMT2AALDH1A1MEN1RXFP1
SCHEMBL3227136 0.82 MAPT (0.72) MAPTKMT2AALDH1A1MEN1RXFP1
SCHEMBL22089531 0.81 MAPT (0.46) MAPTKMT2AALDH1A1MEN1RXFP1
SCHEMBL22115292 0.81 KDM4E (0.48) MAPTKMT2AALDH1A1MEN1RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111303146-A 3-cyanopyridine compound, pharmaceutical composition containing same, preparation method and application thereof 中国科学院上海药物研究所 2020-06-19 CN disclosed
WO-2020119590-A1 3-CYANOPYRIDINE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, PREPARATION METHOD THEREFOR, AND USES THEREOF. 中国科学院上海药物研究所 2020-06-18 WO disclosed