Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.72 |
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | GAA | P10253 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316100 | 0.87 | KDM4E (0.57) | MAPTALDH1A1KMT2AMEN1RXFP1 | |
| SCHEMBL10746252 | 0.87 | ALDH1A1 (0.56) | MAPTALDH1A1KMT2AMEN1RXFP1 | |
| SCHEMBL9673214 | 0.86 | ALDH1A1 (0.55) | MAPTALDH1A1KMT2AMEN1RXFP1 | |
| SCHEMBL4105396 | 0.86 | MAPT (0.58) | MAPTALDH1A1KMT2AMEN1RXFP1 | |
| SCHEMBL10748109 | 0.85 | MAPT (0.54) | MAPTALDH1A1KMT2AMEN1RXFP1 | |
| SCHEMBL10746820 | 0.85 | KDM4E (0.53) | MAPTALDH1A1KMT2AMEN1RXFP1 | |
| SCHEMBL22115166 | 0.85 | MAPT (0.56) | MAPTALDH1A1KMT2AMEN1RXFP1 | |
| SCHEMBL10378084 | 0.84 | ALDH1A1 (1.00) | MAPTALDH1A1KMT2AMEN1RXFP1 | |
| SCHEMBL10748498 | 0.84 | ALDH1A1 (0.53) | MAPTALDH1A1KMT2AMEN1RXFP1 | |
| SCHEMBL3587530 | 0.83 | MAPT (0.55) | MAPTALDH1A1KMT2AMEN1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4371982-A2 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX Pharmaceuticals, Inc. (US) | 2024-05-22 | — | — | EP | disclosed |
| EP-3583096-B1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS INC (US) | 2024-03-27 | — | — | EP | disclosed |
| US-20230133667-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS INC (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230133667-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS INC (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230077268-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. | 2023-03-09 | — | — | US | disclosed |
| CN-110520413-B | Macrocyclic broad spectrum antibiotics | 阿奇克斯制药公司 | 2023-02-17 | — | — | CN | disclosed |
| US-11427558-B1 | Indazoles and azaindazoles as LRRK2 inhibitors | ESCAPE Bio, Inc. (US) | 2022-08-30 | — | — | US | disclosed |
| EP-3997081-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | Escape Bio, Inc. (US) | 2022-05-18 | — | — | EP | disclosed |
| CN-114450274-A | Indazoles and azaindazoles as LRRK2 inhibitors | 伊斯凯普生物公司 | 2022-05-06 | — | — | CN | disclosed |
| US-20210198316-A9 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED (GB) | 2021-07-01 | — | — | US | disclosed |
| US-4849522-A | Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS (US) | 1989-07-18 | — | — | US | disclosed |
| US-4769380-A | Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-09-06 | — | — | US | disclosed |
| US-4732982-A | Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-22 | — | — | US | disclosed |
| US-4731371-A | Certain 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles which are useful as cardiotonic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-15 | — | — | US | disclosed |
| US-4657919-A | CARDIOVASCULAR DISORDERS | E. I. DU PONT DE NEMOURS & CO. (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0124090-B1 | 5-ACYL-2-(1H)-PYRIDINONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-01 | — | — | EP | disclosed |
| US-4568751-A | 5-Acyl-2-(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-02-04 | — | — | US | disclosed |
| US-4555517-A | Pyridone esters as inotropic agents | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1985-11-26 | — | — | US | disclosed |
| EP-0140375-A2 | Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-05-08 | — | — | EP | disclosed |
| EP-0124090-A1 | 5-Acyl-2-(1H)-pyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-11-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11427558-B1 | Indazoles and azaindazoles as LRRK2 inhibitors | LRRK2, PARK7, GDI2 | MAPT 66/4885ALDH1A1 1904/4885KMT2A 361/4885 |
| US-20230077268-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | LRRK2, PARK7, GDI2 | MAPT 66/4885ALDH1A1 1904/4885KMT2A 361/4885 |
| US-20210198316-A9 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | MRPL21, PEPD, CTSC | MAPT 4006/4885ALDH1A1 2364/4885KMT2A 3283/4885 |
| US-20230133667-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | MRPL21, PEPD, CTSC | MAPT 4006/4885ALDH1A1 2364/4885KMT2A 3283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.