Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10053024 | 0.84 | TDP1 (0.66) | NAMPTTDP1KMT2AKDM4EMAPK1 | |
| SCHEMBL11745723 | 0.82 | KMT2A (0.58) | NAMPTTDP1KMT2AMAPK1HTT | |
| SCHEMBL4035829 | 0.82 | TDP1 (0.59) | NAMPTTDP1KMT2AKDM4EMAPK1 | |
| SCHEMBL24810856 | 0.81 | KDM4E (0.45) | NAMPTTDP1KMT2AKDM4EMAPK1 | |
| SCHEMBL10520613 | 0.81 | NAMPT (0.59) | NAMPTTDP1KMT2AKDM4EMAPK1 | |
| SCHEMBL15134825 | 0.81 | NAMPT (0.59) | NAMPTTDP1KMT2AKDM4EMAPK1 | |
| SCHEMBL4578431 | 0.79 | KMT2A (0.52) | TDP1KMT2AKDM4EHTTMEN1 | |
| SCHEMBL4578439 | 0.79 | KMT2A (0.52) | TDP1KMT2AKDM4EHTTMEN1 | |
| SCHEMBL10272740 | 0.79 | TDP1 (0.62) | TDP1KMT2AKDM4EHTTMEN1 | |
| SCHEMBL19884756 | 0.79 | ALDH1A1 (0.47) | NAMPTTDP1KMT2AKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020123836-A2 | HERBOXIDIENE SPLICING MODULATOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2020-06-18 | — | — | WO | disclosed |