Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC16A3 | O15427 | 10/20 | 0.89 |
| ▸ | SLC16A7 | O60669 | 1/20 | 0.89 |
| ▸ | SLC16A8 | O95907 | 1/20 | 0.89 |
| ▸ | HTR5A | P47898 | 1/20 | 0.89 |
| ▸ | POLB | P06746 | 4/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Msc-4381 SCHEMBL31019750 | 0.94 | SLC16A3 (1.00) | SLC16A3SLC16A7SLC16A8HTR5APOLB | |
| Msc-4381 SCHEMBL22116621 | 0.94 | SLC16A3 (1.00) | SLC16A3SLC16A7SLC16A8HTR5APOLB | |
| SCHEMBL22116778 | 0.88 | SLC16A3 (0.90) | SLC16A3SLC16A7SLC16A8HTR5APOLB | |
| SCHEMBL30182486 | 0.87 | SLC16A3 (0.77) | SLC16A3SLC16A7SLC16A8HTR5APOLB | |
| SCHEMBL24109639 | 0.87 | SLC16A3 (0.77) | SLC16A3SLC16A7SLC16A8HTR5APOLB | |
| SCHEMBL22116838 | 0.86 | SLC16A3 (0.76) | SLC16A3SLC16A7SLC16A8HTR5APOLB | |
| SCHEMBL22116501 | 0.85 | SLC16A3 (0.84) | SLC16A3SLC16A7SLC16A8HTR5APOLB | |
| SCHEMBL30188226 | 0.85 | SLC16A3 (1.00) | SLC16A3SLC16A7SLC16A8HTR5APOLB | |
| SCHEMBL22116679 | 0.85 | SLC16A3 (1.00) | SLC16A3SLC16A7SLC16A8HTR5APOLB | |
| SCHEMBL22134858 | 0.84 | SLC16A3 (0.73) | SLC16A3SLC16A7SLC16A8HTR5APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12351570-B2 | Disubstituted alkyne derivatives | MERCK PATENT GMBH (DE) | 2025-07-08 | — | — | US | disclosed |
| US-20230052586-A1 | DISUBSTITUTED ALKYNE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-02-16 | — | — | US | disclosed |
| US-20230052586-A1 | DISUBSTITUTED ALKYNE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-02-16 | — | — | US | disclosed |
| EP-3898588-B1 | DISUBSTITUTED ALKYNE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-01-11 | — | — | EP | disclosed |
| EP-3898588-B1 | DISUBSTITUTED ALKYNE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-01-11 | — | — | EP | disclosed |
| WO-2021249969-A1 | COMBINATION PRODUCT FOR THE TREATMENT OF CANCER DISEASES | MERCK PATENT GMBH (DE) | 2021-12-16 | — | — | WO | disclosed |
| WO-2021249969-A1 | COMBINATION PRODUCT FOR THE TREATMENT OF CANCER DISEASES | MERCK PATENT GMBH (DE) | 2021-12-16 | — | — | WO | disclosed |
| EP-3898588-A1 | DISUBSTITUTED ALKYNE DERIVATIVES | Merck Patent GmbH (DE) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020127960-A1 | DISUBSTITUTED ALKYNE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020127960-A1 | DISUBSTITUTED ALKYNE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12351570-B2 | Disubstituted alkyne derivatives | BRCA1, MYC, PCNA | SLC16A3 3198/4885SLC16A7 3694/4885SLC16A8 3364/4885 |
| US-20230052586-A1 | DISUBSTITUTED ALKYNE DERIVATIVES | BRCA1, MYC, PCNA | SLC16A3 3198/4885SLC16A7 3694/4885SLC16A8 3364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.